Piperacillin-tazobactam: Difference between revisions
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(Created page with "== Background == === Clinical Breakpoints === {| class="wikitable" ! rowspan="2" |Species ! rowspan="2" |ECV (μg/mL) ! colspan="4" |Breakpoints (μg/mL) ! colspan="4" |Break...") |
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== |
==Background== |
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=== |
===Clinical Breakpoints=== |
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{| class="wikitable" |
{| class="wikitable" |
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! rowspan="2" |Species |
! rowspan="2" |Species |
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! rowspan="2" |ECV (μg/mL) |
! rowspan="2" |ECV (μg/mL) |
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! colspan=" |
! colspan="3" |Breakpoints (μg/mL) |
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! colspan=" |
! colspan="3" |Breakpoints (mm) |
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|- |
|- |
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!S |
!S |
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!I |
!I |
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!SDD |
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!R |
!R |
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!S |
!S |
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!I |
!I |
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!SDD |
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!R |
!R |
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|- |
|- |
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|≤16/4 |
|≤16/4 |
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|32/4-64/4 |
|32/4-64/4 |
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|— |
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|≥128/4 |
|≥128/4 |
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|≥21 |
|≥21 |
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|18-20 |
|18-20 |
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|— |
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|≤17 |
|≤17 |
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|- |
|- |
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|≤16/4 |
|≤16/4 |
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|32/4-64/4 |
|32/4-64/4 |
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|— |
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|≥128/4 |
|≥128/4 |
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|≥21 |
|≥21 |
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|15-20 |
|15-20 |
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|— |
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|≤14 |
|≤14 |
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|- |
|- |
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|[[Acinetobacter |
|[[Acinetobacter]] |
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| |
| |
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|≤16/4 |
|≤16/4 |
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|32/4-64/4 |
|32/4-64/4 |
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|— |
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|≥128/4 |
|≥128/4 |
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|≥21 |
|≥21 |
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|18-20 |
|18-20 |
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|— |
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|≤17 |
|≤17 |
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|- |
|- |
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|≤16/4 |
|≤16/4 |
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|32/4-64/4 |
|32/4-64/4 |
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|— |
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|≥128/4 |
|≥128/4 |
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| ⚫ | |||
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|≤16/4 |
|≤16/4 |
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|32/4-64/4 |
|32/4-64/4 |
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|— |
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|≥128/4 |
|≥128/4 |
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| ⚫ | |||
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|≤1/4 |
|≤1/4 |
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|— |
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|— |
|— |
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|≥2/4 |
|≥2/4 |
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|≥21 |
|≥21 |
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|— |
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|— |
|— |
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|— |
|— |
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|- |
|- |
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|Gram-positive bacteria |
|Gram-positive bacteria |
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| colspan=" |
| colspan="7" |susceptibility predicted by [[penicillin]] |
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|} |
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== Dosing == |
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* Standard dose: 3.375 g IV every 6 hours |
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* [[Pseudomonas aeruginosa|Pseudomonas]] dose: 4.5 g IV every 6 hours |
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=== Renal Dosing === |
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{| class="wikitable" |
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!CrCl |
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!Standard |
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![[Pseudomonas aeruginosa|Pseudomonas]] |
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!Notes |
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|- |
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|>30 |
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|3.375 g q6h |
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|4.5 g q6h |
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| ⚫ | |||
|- |
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|10-29 |
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|3.375 g q8h |
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|4.5 g q8h |
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| ⚫ | |||
|- |
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|<10 |
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|3.375 g q12h |
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|4.5 g q12h |
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| |
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|- |
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|PD |
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|3.375 g q12h |
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|4.5 g q12h |
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|- |
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|HD |
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|3.375 g q12h |
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|4.5 g q12h |
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|On dialysis days, given towards the end of dialysis |
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|- |
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|CRRT |
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|3.375 g q6h |
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|4.5 g q6h |
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|- |
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|SLED |
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|3.375 g q12-18h |
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|4.5 g q12-18h |
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|Depends on severity of illness and intensity of SLED dialysis |
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|} |
|} |
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[[Category:Β-lactams]] |
[[Category:Β-lactams]] |
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Latest revision as of 15:07, 9 January 2024
Background
Clinical Breakpoints
| Species | ECV (μg/mL) | Breakpoints (μg/mL) | Breakpoints (mm) | ||||
|---|---|---|---|---|---|---|---|
| S | I | R | S | I | R | ||
| Enterobacterales | ≤16/4 | 32/4-64/4 | ≥128/4 | ≥21 | 18-20 | ≤17 | |
| Pseudomonas aeruginosa | ≤16/4 | 32/4-64/4 | ≥128/4 | ≥21 | 15-20 | ≤14 | |
| Acinetobacter | ≤16/4 | 32/4-64/4 | ≥128/4 | ≥21 | 18-20 | ≤17 | |
| Other non-Enterobacterales | ≤16/4 | 32/4-64/4 | ≥128/4 | ||||
| Anaerobes | ≤16/4 | 32/4-64/4 | ≥128/4 | ||||
| Haemophilus influenzae and Haemophilus parainfluenzae | ≤1/4 | — | ≥2/4 | ≥21 | — | — | |
| Gram-positive bacteria | susceptibility predicted by penicillin | ||||||
Dosing
- Standard dose: 3.375 g IV every 6 hours
- Pseudomonas dose: 4.5 g IV every 6 hours
Renal Dosing
| CrCl | Standard | Pseudomonas | Notes |
|---|---|---|---|
| >30 | 3.375 g q6h | 4.5 g q6h | |
| 10-29 | 3.375 g q8h | 4.5 g q8h | |
| <10 | 3.375 g q12h | 4.5 g q12h | |
| PD | 3.375 g q12h | 4.5 g q12h | |
| HD | 3.375 g q12h | 4.5 g q12h | On dialysis days, given towards the end of dialysis |
| CRRT | 3.375 g q6h | 4.5 g q6h | |
| SLED | 3.375 g q12-18h | 4.5 g q12-18h | Depends on severity of illness and intensity of SLED dialysis |
