View source for Pharmacokinetics and pharmacodynamics

== Background ==

* '''Pharmacokinetics''' refers to the movement of drug through the body, and is characterized by absorption, distribution, metabolism, and excretion
* '''Pharmacodynamics''' refers to the effect of the drug on the body

== Antimicrobials ==
{| class="wikitable"
!Antimicrobial
!Bactericidal Pattern
!PK-PD Measure
|-
|[[aminoglycosides]]
|concentration-dependent
|AUC<sub>0-24</sub>:MIC, C<sub>max</sub>:MIC
|-
|[[β-lactams]]
|time-dependent
|T>MIC
|-
|[[clindamycin]]
|time-dependent
|AUC<sub>0-24</sub>:MIC
|-
|[[daptomycin]]
|concentration-dependent
|AUC<sub>0-24</sub>:MIC, C<sub>max</sub>:MIC
|-
|[[vancomycin]]
|time-dependent
|AUC<sub>0-24</sub>:MIC
|-
|[[azithromycin]]
|time-dependent
|AUC<sub>0-24</sub>:MIC
|-
|[[clarithromycin]]
|time-dependent
|AUC<sub>0-24</sub>:MIC
|-
|[[metronidazole]]
|concentration-dependent
|AUC<sub>0-24</sub>:MIC, C<sub>max</sub>:MIC
|-
|[[linezolid]]
|time-dependent
|AUC<sub>0-24</sub>:MIC
|-
|[[fluoroquinolones]]
|concentration-dependent
|AUC<sub>0-24</sub>:MIC, C<sub>max</sub>:MIC
|-
|[[doxycycline]]
|time-dependent
|AUC<sub>0-24</sub>:MIC
|-
|[[tigecycline]]
|time-dependent
|AUC<sub>0-24</sub>:MIC
|}

==Further Reading==

*Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore. ''Clin Infect Dis''. 2007;44(1):79-86. doi: [https://doi.org/10.1086/510079 10.1086/510079]