View source for Drug-induced thrombotic microangiopathy

== Background ==

* A [[thrombotic microangiopathy]] caused by exposure to certain medications
* May present with a [[TTP]]- or [[HUS]]-like syndrome
* Variable and unceratain pathophysiology; likely some immune-mediated and some directly toxic
* Associations that are probably true include: [[bevacizumab]], [[cocaine]], [[Cyclosporine|'''cyclosporine''']], [[docetaxel]], [[everolimus]], [[gemcitabine]], [[interferon α]], [[interferon β]], [[interferon polycarboxylate]], [[mitomycin]], [[muromonab-CD3]], [[oxaliplatin]], [[penicillin]], [[pentostatin]], [[quetiapine]], [[Quinine|'''quinine''']], [[sirolimus]], [[sulfisoxazole]], [[sunitinib]], [[Tacrolimus|'''tacrolimus''']], [[trielina]], and [[vincristine]][[CiteRef::al-nouri2015dr]]

== Further Reading ==

* Drug-induced thrombotic microangiopathy: a systematic review of published reports. ''Blood''. 2015 Jan 22;125(4):616-8. doi: [https://doi.org/10.1182/blood-2014-11-611335 10.1182/blood-2014-11-611335]. PMID: [[25414441]]; PMCID: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304106/ PMC4304106].

[[Category:Thrombotic microangiopathies]]