View source for Γ-glutamyltransferase

{{DISPLAYTITLE:γ-glutamyltransferase}}

[[Category:Investigations]]
{{DEFAULTSORT:gamma-glutamyltransferase}}

== Background ==

* Liver enzyme in microsomes that catalyzes transfer of γ-glutamyl group from peptides to other amino acids

== Interpretation ==

* About 90% sensitive for [[cholestasis]] (with ALP)
**Often only rise after several days
* Isolated elevation of GGT may be caused by enzyme induction from [[Alcohol use disorder|alcohol]] or aromatic medications, without liver disease[[CiteRef::PMID10221307]]
** Aromatic medications include, commonly, [[phenobarbital]], [[phenytoin]], and others
** Elevation is usually about twice the upper limit of normal
*Can also see isolated elevations in [[COPD]], [[AKI]] or [[CKD]], and [[acute myocardial infarction]][[CiteRef::giannini2005li]]
*May be elevated in [[NAFLD]] and [[hepatitis C]] and other liver or biliary diseases