View source for Pseudomonas aeruginosa

= ''Pseudomonas aeruginosa'' =

== Microbiology ==

* Oxidase-positive, non-fermenting Gram negative bacillus

== Mechanisms of Resistance ==

* Broad intrinsic and acquired antibiotic resistance
* Membrane impermeability
* MexAB-OprM efflux pump
* Acquired mutations
* Inducible AmpC β-lactamase
* Plasmid sharing

== Environment and Infections ==

* Loves moist and wet environments
* Causes healthcare-associated infections
** UTI, SSI, bacteremia, HAP, VAP
** Especially common in cystic fibrosis

== Treatment ==

* See [Antipseudomonal antibiotics](/Infectious Diseases/Basics/Antimicrobials/Antipseudomonal antibiotics.md)
* Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection