Background
- β-lactam-β-lactamase inhibitor antibiotic
- Half-life 2.15 and 2.52 hours, respectively
Dosing
- Hospital-acquired pneumonia/ventilator-associated pneumonia caused by Acinetobacter baumannii complex: 2 g IV over 3 hours q6h for 7 to 14 days
Renal Dosing
| CrCl | Dose |
|---|---|
| ≥130 | 2 g q4h |
| 45-129 | normal dose, 2 g q6h |
| 30-44 | 2 g q8h |
| 15-29 | 2 g q12h |
| <15 | 2 g q12h x3 doses followed by q24h |
| IHD | 2 g q12h x3 doses followed by q24h |
| CRRT | Based on EFR |
Safety
Adverse Effects
- Routine for antibiotics: hypersensitivity and Clostridioides difficile
- Elevated liver enzyes
- Diarrhea
- Anemia
- Hypokalemia
