Sudden onset edematous, erythematous lesions (can be papules, nodules, or plaques)
Fever, leukocytosis
Diagnostic Criteria
Classical Sweet Syndrome
Requires both major criteria and at least 2 minor criteria
Major criteria:
Abrupt onset of painful erythematous plaques or nodules
Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis
Minor criteria:
Fever greater than 38 Celsius
Underlying hematologic or solid-organ malignancy, inflammatory disease, or pregnancy; or preceded by an upper respiratory or GI infection or vaccination
Excellent response to systemic corticosteroids or potassium iodide
Abnormal bloodwork at presentation, with at least 3 of: ESR >20 mm/h, elevated CRP, WBC >8, neutrophils >70%
Drug-Induced Sweet Syndrome
Requires the presence of all five criteria
Criteria:
Abrupt onset of painful erythematous plaques or nodules
Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis
Fever greater than 38 Celsius
Temporal relationship between drug ingestion and clinical presentation, or temporally-related recurrence after oral challenge
Temporal relationship between drug withdrawal or treatment with systemic corticosteroids and resolution of lesions
