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...n::peripheral neuropathy]], [[Adverse drug reaction::CNS toxicity]], and [[Adverse drug reaction::sideroblastic anemia]] * Taking concurrent pyridoxine 25 mg po daily can decrease risk of neuropathy

...verse drug reaction::rash]], [[Adverse drug reaction::arthralgias]], and [[Adverse drug reaction::gout]] ** Most likely part of standard tuberculosis therapy to cause hepatitis

* Antimicrobial that inhibits the reduction of dihydrofolic to tetrahydrofolic acid * Major adverse effects is bone marrow suppression, so need to monitor CBC

* Recombinant proteins that bind to two different antigens, one of which activates T cells and the other binds a cancer target === Adverse Effects ===

=== Adverse Effects === * Orange or red discoloration of body fluids

* Mechanism of action is unknown, but postulated to be redox cycling and membrane destabil === Adverse Effects ===

=== Mechanism of Action === * Inhibits the 50S ribosome of Gram-positive bacteria

*Direct effects on intestinal tract ...y cause an acute, hemorrhagic [[segmental colitis]], usually within 4 days of therapy

...r unknown; if at least a possible relationship exists, it is considered an adverse reaction ...eaction''' is one that requires inpatient hospitalization (or prolongation of existing hospitalization), causes congenital malformation, results in persi

* Most commonly starts after 4 to 7 days of exposure * Generally self-limited following withdrawal of offending medication

===Mechanism of Action=== ...ds 30S ribosomal subunit, which stops proofreading and causes accumulation of bad proteins

**''M. africanum'': 50% of cases in West africa *About a third of the world is infected, mostly as latent tuberculosis