Penicillin-binding protein
From IDWiki
- A group of enzymes including transpeptidases, carboxypeptidases, and endopeptidases that play a role in the formation and maintenance of the cell wall structure
| Class A | Class B | Class C | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A1 | A2 | A3 | A4 | A5 | A6 | A7 | B1 | B2 | B3 | B4 | B5 | B5 | B6 | B-like-I | B-like-II | B-like-III | Type-4 | Type-5 | Type-7 | Type-AmpH | |
| Gram-Negative Bacteria | |||||||||||||||||||||
| Escherichia coli | PBP1a
ponA |
PBP1b
ponB |
PBP1c
pbpC |
MGT
mgt |
PHP2
pbpA |
PHP3
ftsI |
PBP4
dacB |
PBP5, PHP6, PHP6b
dacA, dacC, dacD |
PBP7
pbpG |
PBP4b, AmpH
yefw, ampH | |||||||||||
| Neisseria gonorrhoeae | PBP1
ponA |
PBP2
ftsI |
PBP3
pbp3 |
PBP4
pbp4 |
|||||||||||||||||
| Gram-Positive Bacteria | |||||||||||||||||||||
| Staphylococcus aureus | PBP2
pbp2 |
MGT
mgt |
PBP2a
mecA |
PBP1
pbpA |
PBP3
pbp3 |
PBP4
pbp4 |
|||||||||||||||
| Listeria monocytogenes | PBP1 | PBP4 | PBP | PBP2 | PBP3 | PBP5 | |||||||||||||||
| Enterococcus faecalis | PBP1a | PBP2a | PBP1b | PBP4 | PBP2 | PBP2b | DacF | ||||||||||||||
| Streptococcus pneumoniae | PBP1a
pbpA |
PBP2a
pbp2& |
PBP1b
pbp1b |
PBP2x
pvpX |
PBP2b
pbp2b |
PBP3
pbp3 |
|||||||||||||||
| Other Bacteria | |||||||||||||||||||||
| Mycobacterium tuberculosis | PBP1
ponA1 |
PBP1A (r)
ponA2 |
PBPA
pbpA |
PBP2
pbpB |
PBP-lipo
Rv2864c |
PBP4
Rv3627 |
PBP5
dacB1 |
PBP7
dacB2 |
PBP | ||||||||||||
PBP Mutations
- Escherichia coli: PBP3 insert (YRIN/YRIK)
- Klebsiella pneumoniae: PBP1, PBP2, and PBP3
- Pseudomonas aeruginosa: PBP1 and PBP3
- Acinetobacter baumannii: PHP3-H370Y, PBP3-Q488K and Y528H
Antibiotic Targets
- MSSA
- Cefazolin: primarily PBP2, but all except PBP4
- Ertapenem: PBP1
- Cefaclor: PBP3
- Cefoxitin: PBP4
