Aspergillus udagawae

Background

• Species of mold within the genus Aspergillus

Clinical Manifestations

• Rare cases of infection in humans
• Cases that I could find in Pubmed in October 2024:
  • Fungal canaliculitis in an immunocompetent patient, managed with drainage alone1
  • Fungal endocarditis in a patient with ALL that was fatal despite voriconazole2
  • Disseminated disease in a patient on chemotherapy for MDS3
  • 4 cases of invasive fungal pulmonary infection in 3 patients with CGD and 1 with MDS4
    • All patients required long courses with more treatment failures than comparable patients with Aspergillus fumigatus
    • 2 patients died
  • 2 cases of pulmonary infections in patients with malignancies5
  • Bronchial infection in a patient with diabetes mellitus that was successfully treated with voriconazole6
  • Fungal keratitis in a healthy patient with clinical failure on itraconazole7

Management

• Increased MICs compared to Aspergillus fumigatus and frequent clinical failures of antifungals
• No clinical breakpoints are available given the rarity of the species