Chronic granulomatous disease

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Background

Pathophysiology

  • Defect in NADPH oxidase
  • Therefore unable to generate superoxide radicals required by phagocytes to kill pathogens

Clinical Manifestations

Differential Diagnosis

Diagnosis

  • The diagnosis is confirmed with the dihydrohodamine-123 (DHR-123) test

Management

Further Reading

  • Considerations in the Diagnosis of Chronic Granulomatous Disease. J Pediatric Infect Dis Soc. 2018;7(S1):S6-S11. doi: 10.1093/jpids/piy007