| Drug
|
Mutation
|
Notes
|
| NRTIs
|
| 69 insertion complex
|
M41L
|
multi-NRTI resistance
|
| A62V
|
| * 69 insert
|
| K70R
|
| L210W
|
| T215YF
|
| K219QE
|
| 151 complex
|
A62V
|
multi-NRTI resistance
|
| V75I
|
| F77L
|
| F116Y
|
| Q151M
|
| Thymidine analogue-associated mutations (TAMs)
|
M41L
|
resistance to AZT and d4T; resistance to others is proportional to the number of TAMs, and with 4 or more mutations there is resistance to essentially all NRTIs
|
| D67N
|
| K70R
|
| L210W
|
| T215Y/F
|
| K219Q/W
|
| Abacavir
|
K65R/E/N
|
common
|
| L74V
|
|
| Y115F
|
|
| M184V
|
common; can still use TDF, AZT
|
| Emtricitabine
|
K65R/E/N
|
common
|
| M184V/I
|
common; can use ABC (if M184I), TDF, AZT; can still use FTC in combination with TDF or TAF
|
| Lamivudine
|
K65R/E/N
|
common
|
| M184V/I
|
common; can use ABC (if M184I), TDF, AZT; can still use 3TC in combination with TDF or TAF
|
| Tenofovir
|
K65R/E/N
|
common
|
| K70E
|
|
| Zidovudine
|
M41L
|
|
| D67N
|
|
| K70R
|
|
| L210W
|
|
| T215Y/F
|
|
| K219Q/E
|
|
| NNRTIs
|
| Doravirine
|
V106A/I/M/T
|
|
| Y188C/L/H
|
|
| G190E
|
|
| P225H
|
|
| F227C/L/R
|
|
| M230L
|
|
| L234I
|
|
| Efavirenz
|
L100I
|
|
| K101P
|
|
| K103N/S
|
|
| V106M
|
|
| V108I
|
|
| Y181C/I
|
|
| Y188L
|
|
| G190S/A
|
|
| P225H
|
|
| M230L
|
|
| Nevirapine
|
L100I
|
|
| K101P
|
|
| K103N/S
|
|
| V106A/M
|
|
| V108I
|
|
| Y181C/I
|
common
|
| Y188C/L/H
|
|
| G190A
|
|
| M230L
|
|
| Rilpivirine
|
L100I
|
|
| K101E/P
|
common
|
| E138A/G/K/Q/R
|
common
|
| V179L
|
|
| Y181C/I/V
|
common
|
| Y188L
|
|
| H221Y
|
|
| F227C
|
|
| M230I/L
|
|
| Protease inhibitors
|
| Atazanavir
|
L10I/F/V/C
|
|
| G16E
|
|
| K20R/M/I/T/V
|
|
| L24I
|
|
| V32I
|
|
| L33I/F/V
|
|
| E34Q
|
|
| M36I/L/V
|
|
| M46I/L
|
|
| G48V
|
|
| I50L
|
common
|
| F53L/Y
|
|
| I54L/V/M/T/A
|
|
| D60E
|
|
| I62V
|
|
| I64L/M/V
|
|
| A71V/I/T/L
|
|
| G73C/S/T/A
|
|
| V82A/T/F/I
|
|
| I84V
|
|
| I85V
|
|
| N88S
|
|
| L90M
|
|
| I93L/M
|
|
| Darunavir
|
V11I
|
|
| V32I
|
|
| L33F
|
|
| I47V
|
|
| I50V
|
|
| I54M/L
|
|
| T74P
|
|
| L76V
|
|
| I84V
|
|
| L89V
|
|
| INSTIs
|
| Bictegravir
|
G118R
|
|
| E138K
|
|
| G140S
|
|
| Q148H
|
|
| R263K
|
|
| Cabotegravir
|
T66K
|
|
| G118R
|
|
| E138A/K/T
|
|
| G140A/C/R/S
|
|
| Q148H/K/R
|
|
| S153F/Y
|
|
| N155H
|
|
| R263K
|
|
| Dolutegravir
|
G118R
|
|
| F121Y
|
|
| E138A/K/T
|
|
| G140A/S
|
|
| Q148H/K/R
|
|
| N155H
|
|
| R263K
|
common
|
| Elvitegravir
|
T66I/A/K
|
|
| E92Q/G
|
|
| T97A
|
|
| F121Y
|
|
| S147G
|
|
| Q148H/K/R
|
common
|
| N155H
|
common
|
| R263K
|
|
| Raltegravir
|
L74M
|
|
| E92Q
|
|
| T97A
|
|
| F121Y
|
|
| E138A/K
|
|
| G140A/S
|
|
| Y143R/H/C
|
common
|
| Q148H/K/R
|
common
|
| N155H
|
common
|
| R263K
|
|
