Bacterial infection of the urinary tract, either lower (cystitis) or upper (pyelonephritis)
When UTI causes sepsis syndrome, often referred to as urosepsis
Diagnostic criteria include clinical and laboratory symptoms:
Two or more clinical symptoms:
Fever > 38ºC
Urinary urgency or frequency
Acute dysuria
Hypogastric pain
Costovertebral angle tenderness
One or more laboratory finding:
Bacteriuria (> 100,000 CFUs/mL)
Pyuria (>10 WBCs/HPF)
Etiology
Typical organisms include:
E. coli
S. saprophicitus
Investigations
Labs
Urinalysis has high NPV (~100%) if negative for leukocyst esterase and nitrites is negative
References
^Dimitri M. Drekonja, Barbara Trautner, Carla Amundson, Michael Kuskowski, James R. Johnson. Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection. JAMA. 2021;326(4):324. doi:10.1001/jama.2021.9899.
