Tissue penetration of antimicrobials: Difference between revisions

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(Created page with "{| class="wikitable" !Class !Antimicrobial !Blood !CNS !Urine |- |Penicillins |β-lactamase inhibitors | |NO | |- |Cephalosporins |First- and second-generation cephalosporins...")
 
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!CNS
  
!CNS
 
!Urine
  
!Urine
  +
!Necrotic
 
|-
  
|-
  +
! colspan="6" |Antibiotics
⚫
|Penicillins
  
  +
|-
  ⚫
| rowspan="2" |Penicillins
 
|β-lactamase inhibitors
  
|β-lactamase inhibitors
 
|
  
|
 
|NO
  
|NO
  +
|
 
|
  
|
 
|-
  
|-
  +
|[[ampicillin]]
⚫
|Cephalosporins
  
⚫
|First- and second-generation cephalosporins
  
 
|
  
|
−
|NO
 +
|YES
 
|
  
|
  +
|NO
 
|-
  
|-
  ⚫
| rowspan="3" |Cephalosporins
⚫
|Cephamycins
  
  ⚫
|first- and second-generation cephalosporins
 
|
  
|
  +
|NO
 
|
  
|
 
|NO
  
|NO
  +
|-
  +
|[[cefepime]]
 
|
  
|
  +
|
  +
|
  +
|YES
 
|-
  
|-
  +
|[[ceftazidime]]
⚫
|Carbapenems
  
 
|
  
|
  +
|YES
 
|
  
|
  +
|YES
  +
|-
  ⚫
| rowspan="2" |Cephamycins
  +
|[[cephamycins]]
  +
|
  +
|NO
 
|
  
|
 
|
  
|
 
|-
  
|-
  +
|[[cefoxitin]]
⚫
|Lincosamides
  
  +
|
⚫
|[[clindamycin]]
  
  +
|
 
|
  
|
 
|NO
  
|NO
  +
|-
  ⚫
|Carbapenems
  +
|[[imipenem]]
  +
|
  +
|
 
|
  
|
  +
|YES
  +
|-
  +
|Aminoglycosides
  +
|
  +
|
  +
|
  +
|
  +
|NO
 
|-
  
|-
 
|Fluoroquinolones
  
|Fluoroquinolones
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|NO?
  
|NO?
 
|
  
|
  +
|YES
  +
|-
  ⚫
|Lincosamides
  ⚫
|[[clindamycin]]
  +
|
  +
|NO
  +
|
  +
|YES
 
|-
  
|-
 
|Macrolides
  
|Macrolides
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|
  
|
 
|NO
  
|NO
  +
|
 
|
  
|
 
|-
  
|-
  +
|Nitroimidazoles
⚫
|Tetracyclines
  
  +
|[[metronidazole]]
 
|
  
|
  +
|
  +
|
  +
|YES
  +
|-
  ⚫
| rowspan="2" |Tetracyclines
  +
|[[tetracyclines]]
 
|
  
|
 
|NO
  
|NO
 
|
  
|
  +
|
  +
|-
  +
|[[doxycycline]]
  +
|
  +
|
  +
|
  +
|YES
  +
|-
  +
|Chloramphenicol
  +
|[[chloramphenicol]]
  +
|
  +
|
  +
|
  +
|YES
  +
|-
  +
! colspan="6" |Antifungals
  +
|-
  +
|Azoles
  +
|[[fluconazole]]
  +
|
  +
|
  +
|
  +
|YES
 
|}
  
|}
 
[[Category:Antimicrobials]]
  
[[Category:Antimicrobials]]

Revision as of 09:47, 24 August 2020

Class Antimicrobial Blood CNS Urine Necrotic
Antibiotics
Penicillins β-lactamase inhibitors NO
ampicillin YES NO
Cephalosporins first- and second-generation cephalosporins NO NO
cefepime YES
ceftazidime YES YES
Cephamycins cephamycins NO
cefoxitin NO
Carbapenems imipenem YES
Aminoglycosides NO
Fluoroquinolones NO? YES
Lincosamides clindamycin NO YES
Macrolides NO
Nitroimidazoles metronidazole YES
Tetracyclines tetracyclines NO
doxycycline YES
Chloramphenicol chloramphenicol YES
Antifungals
Azoles fluconazole YES

References

  1. ^  Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe, Fritz Sörgel. Penetration of Antibacterials into Bone. Clinical Pharmacokinetics. 2009;48(2):89-124. doi:10.2165/00003088-200948020-00002.

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