Tigecycline: Difference between revisions
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+ | ==Background== |
*Glycylcycline antibiotic |
*Glycylcycline antibiotic |
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*Does cover [[Acinetobacter]] and [[Stenotrophomonas]] |
*Does cover [[Acinetobacter]] and [[Stenotrophomonas]] |
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+ | ===Pharmacokinetics and Pharmacodynamics=== |
| − | * |
+ | *Rapidly concentrates in tissue, but poor concentration in urine and lung tissue |
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+ | ==Dosing== |
| − | * |
+ | *'''Intraabdominal infection:''' 100 mg IV load followed by 50 mg IV q12h |
| + | *'''Pneumonia:''' 100 mg IV load followed by 50 mg IV q12h |
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| + | **High dosing may be useful in HAP/VAP with 100 mg IV q12h |
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| + | *'''Skin and soft tissue infection:''' 100 mg IV load followed by 50 mg IV q12h |
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+ | ==Safety== |
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+ | *Black box warning for increased all-cause mortality (4 vs 3%), likely driven by standard dosing tigecycline in VAP |
| + | *Commonly causes nausea, vomiting, and diarrhea |
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| + | *Also anemia, thrombocytopenia, hepatitis, jaundice, AKI |
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[[Category:Glycylcyclines]] |
[[Category:Glycylcyclines]] |
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Latest revision as of 08:56, 26 April 2021
Background
- Glycylcycline antibiotic
Spectrum of Activity
- Related to tetracycline and doxycycline, with expanded coverage to include streptococci and Enterobacteriaceae, but without coverage for unusual Gram-negative bacteria or Chlamydia trachomatis
- Does cover Acinetobacter and Stenotrophomonas
Pharmacokinetics and Pharmacodynamics
- Rapidly concentrates in tissue, but poor concentration in urine and lung tissue
Dosing
- Intraabdominal infection: 100 mg IV load followed by 50 mg IV q12h
- Pneumonia: 100 mg IV load followed by 50 mg IV q12h
- High dosing may be useful in HAP/VAP with 100 mg IV q12h
- Skin and soft tissue infection: 100 mg IV load followed by 50 mg IV q12h
Safety
- Black box warning for increased all-cause mortality (4 vs 3%), likely driven by standard dosing tigecycline in VAP
- Commonly causes nausea, vomiting, and diarrhea
- Also anemia, thrombocytopenia, hepatitis, jaundice, AKI
