Tigecycline: Difference between revisions
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| + | == Background == |
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*Glycylcycline antibiotic |
*Glycylcycline antibiotic |
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| − | == |
+ | ===Spectrum of Activity=== |
*Related to [[tetracycline]] and [[doxycycline]], with expanded coverage to include [[streptococci]] and [[Enterobacteriaceae]], but without coverage for unusual [[Gram-negative bacteria]] or [[Chlamydia trachomatis]] |
*Related to [[tetracycline]] and [[doxycycline]], with expanded coverage to include [[streptococci]] and [[Enterobacteriaceae]], but without coverage for unusual [[Gram-negative bacteria]] or [[Chlamydia trachomatis]] |
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*Does cover [[Acinetobacter]] and [[Stenotrophomonas]] |
*Does cover [[Acinetobacter]] and [[Stenotrophomonas]] |
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| + | === Pharmacokinetics and Pharmacodynamics === |
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| + | * Rapidly concentrates in tissue, but poor concentration in urine and lung tissue |
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| + | == Dosing == |
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| + | * High dosing may be useful in HAP/VAP with 100 mg IV q12h |
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| + | == Safety == |
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| + | * Black box warning for increased all-cause mortality (4 vs 3%), likely driven by standard dosing tigecycline in VAP |
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[[Category:Glycylcyclines]] |
[[Category:Glycylcyclines]] |
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Revision as of 09:29, 3 February 2021
Background
- Glycylcycline antibiotic
Spectrum of Activity
- Related to tetracycline and doxycycline, with expanded coverage to include streptococci and Enterobacteriaceae, but without coverage for unusual Gram-negative bacteria or Chlamydia trachomatis
- Does cover Acinetobacter and Stenotrophomonas
Pharmacokinetics and Pharmacodynamics
- Rapidly concentrates in tissue, but poor concentration in urine and lung tissue
Dosing
- High dosing may be useful in HAP/VAP with 100 mg IV q12h
Safety
- Black box warning for increased all-cause mortality (4 vs 3%), likely driven by standard dosing tigecycline in VAP
