Thromboprophylaxis in pregnancy: Difference between revisions
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Latest revision as of 21:17, 3 July 2020
Indications for prophylaxis
Patient | FHx of VTE? | Prophylaxis |
---|---|---|
Prior VTE with provoked, transient risk factor | — | None |
Prior VTE either unprovoked or estrogen-related | — | Antepartum and postpartum |
Homozygous Factor V Leiden | Yes | Antepartum and postpartum |
Homozygous prothrombin gene mutation | Yes | Antipartum and postpartum |
Antithrombin-III deficiency | Yes | Antepartum and postpartum |
Other thrombophilia | Yes | Postpartum only |
Homozygous Factor V Leiden | No | Postpartum only |
Homozygous prothrombin gene mutation | No | Postpartum only |
Other thrombophilia | No | None |
Antithrombin-III deficiency | No | None |
Prophylaxis regimens
Timing | Management |
---|---|
Antepartum | Prophylactic or intermediate-dose LMWH |
Postpartum | Prophylactic or intermediate-dose LMWH, or warfarin (INR 2-3), for 6 weeks |