Thrombocytosis: Difference between revisions
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* Primary |
* Primary |
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| − | ** Essential thrombocythemia |
+ | ** [[Essential thrombocythemia]] |
| − | ** Polycythemia vera |
+ | ** [[Polycythemia vera]] |
* Secondary |
* Secondary |
||
** Transient process |
** Transient process |
||
*** Acute blood loss |
*** Acute blood loss |
||
| − | *** Rebound from thrombocytopenia |
+ | *** Rebound from [[thrombocytopenia]] |
*** Acute phase reactant in acute infection or inflammatory processes |
*** Acute phase reactant in acute infection or inflammatory processes |
||
*** Response to exercise |
*** Response to exercise |
||
** Sustained process |
** Sustained process |
||
| − | *** Iron deficiency (most common reason for referral to hematologist) |
+ | *** [[Iron deficiency]] (most common reason for referral to hematologist) |
| − | *** Hemolytic anemia |
+ | *** [[Hemolytic anemia]] |
| − | *** Asplenia |
+ | *** [[Asplenia]] |
*** Cancer |
*** Cancer |
||
*** Chronic inflammatory or infectious diseases |
*** Chronic inflammatory or infectious diseases |
||
| − | **** Connective-tissue disorders |
+ | **** [[Connective-tissue disorders]] |
| − | **** Temporal arteritis |
+ | **** [[Temporal arteritis]] |
| − | **** Inflammatory bowel disease |
+ | **** [[Inflammatory bowel disease]] |
| − | **** Tuberculosis |
+ | **** [[Tuberculosis]] |
| − | **** Chronic pneumonitis |
+ | **** [[Chronic pneumonitis]] |
*** Drug reactions |
*** Drug reactions |
||
| − | **** Vincristine |
+ | **** [[Vincristine]] |
| − | **** All-trans-retinoic acid |
+ | **** [[All-trans-retinoic acid]] |
**** Cytokines |
**** Cytokines |
||
**** Growth factors |
**** Growth factors |
||
| − | == Clinical |
+ | == Clinical Manifestations == |
* Primary/clonal more likely if: |
* Primary/clonal more likely if: |
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Latest revision as of 17:29, 9 February 2022
Differential Diagnosis
- Primary
- Secondary
- Transient process
- Acute blood loss
- Rebound from thrombocytopenia
- Acute phase reactant in acute infection or inflammatory processes
- Response to exercise
- Sustained process
- Iron deficiency (most common reason for referral to hematologist)
- Hemolytic anemia
- Asplenia
- Cancer
- Chronic inflammatory or infectious diseases
- Drug reactions
- Vincristine
- All-trans-retinoic acid
- Cytokines
- Growth factors
- Transient process
Clinical Manifestations
- Primary/clonal more likely if:
- Digital ischemia
- Cerebrovascular ischemia
- Large-vessel thrombosis
- Bleeding
- Splenomegaly
- Giant platelets
Investigations
- Labs
- CBC
- Peripheral film, for platelet size
- ESR/CRP, rule out underlying inflammatory disorder
- Other
