Thrombocytosis: Difference between revisions
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Revision as of 06:52, 2 August 2020
Differential Diagnosis
- Primary
- Essential thrombocythemia
- Polycythemia vera
- Secondary
- Transient process
- Acute blood loss
- Rebound from thrombocytopenia
- Acute phase reactant in acute infection or inflammatory processes
- Response to exercise
- Sustained process
- Iron deficiency (most common reason for referral to hematologist)
- Hemolytic anemia
- Asplenia
- Cancer
- Chronic inflammatory or infectious diseases
- Connective-tissue disorders
- Temporal arteritis
- Inflammatory bowel disease
- Tuberculosis
- Chronic pneumonitis
- Drug reactions
- Vincristine
- All-trans-retinoic acid
- Cytokines
- Growth factors
- Transient process
Clinical Manifestations
- Primary/clonal more likely if:
- Digital ischemia
- Cerebrovascular ischemia
- Large-vessel thrombosis
- Bleeding
- Splenomegaly
- Giant platelets
Investigations
- Labs
- CBC
- Peripheral film, for platelet size
- ESR/CRP, rule out underlying inflammatory disorder
- Other
