Thrombocytopenia

Differential Diagnosis

• Decreased production
  • Viral infection
  • Malignancy
• Destruction/Consumption
  • Immune-mediated thrombocytopenic purpura (ITP)
    • Hepatitis C, HIV, and Helicobacter pylori
    • Medications
      • More likely: abciximab, beta-lactams (including penicillins and cephalosporins), carbamazepine, epifitabide, gold compounds, heparin, linezolid, MMR vaccine, phenytoin, piperacillin, quinidine, quinine, rifampin, sulfonamides (including TMP-SMX), valproic acid, and vancomycin
  • Thrombotic microangiopathy
    • TTP/HUS, other TMAs
• Sequestration
  • Splenomegaly

Investigations

• Rule out secondary causes with hepatitis C virus, HIV, and Helicobacter pylori serology