For primary, secondary, or early latent syphilis: benzathine penicillin G 2.4 million units IM weekly for 1-2 doses
For late latent, latent syphilis with unknown duration, or tertiary syphilis not involving the CNS: benzathine penicillin G 2.4 million units IM weekly for 3 doses
For tertiary neurosyphilis, treat as usual
Postpartum, follow guidelines for congenital syphilis to decide whether and how to treat the neonate
