Streptococcus pneumoniae: Difference between revisions
From IDWiki
Streptococcus pneumoniae
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* Major cause of morbidity and mortality in children |
* Major cause of morbidity and mortality in children |
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** Leading cause of under-5 mortality worldwide |
** Leading cause of under-5 mortality worldwide |
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| + | == Pathophysiology == |
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| + | * Acquired by coughing and sneezing |
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| + | * Asymptomatic carriage or colonization in the nasopharynx |
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| + | * Invasion through epithelial cells into the bloodstream, using the PAF and pIg receptors |
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| + | * Capsule and various proteins help it to evade immune system |
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{{DISPLAYTITLE:''Streptococcus pneumoniae''}} |
{{DISPLAYTITLE:''Streptococcus pneumoniae''}} |
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Revision as of 18:32, 2 October 2019
Microbiology
- Gram-positive, lancet-shaped diplococci
- 90+ serotypes, based on capsular polysaccharide that is bound to peptidoglycan
- Lab identification is based on α-hemolysis of blood agar (from pneumolysin), optochin susceptibility, and bile salt solubility
Epidemiology
- Present worldwide
- Major cause of morbidity and mortality in children
- Leading cause of under-5 mortality worldwide
Pathophysiology
- Acquired by coughing and sneezing
- Asymptomatic carriage or colonization in the nasopharynx
- Invasion through epithelial cells into the bloodstream, using the PAF and pIg receptors
- Capsule and various proteins help it to evade immune system
