Small cell lung cancer: Difference between revisions

Revision as of 11:10, 29 July 2020

Staging

TMN

Stage 1: a single lesion ≤3 cm with no lymphadenopathy
Stage 2: ipsilateral lymph nodes and mediastinum
Stage 3: contralateral lymph nodes and metastases
Stage 4: distant metastases

VALSG

Limited stage: disease confined to ipsilateral lung, lymph nodes, and mediastinum, which can be contained within one radiotherapy window
Extensive stage: metastasis to contralateral lung, contralateral lymph nodes, or distant sites

Management

Stage 1

Potentially curative
Surgical resection
- If lymph nodes negative, adjuvant chemotherapy
- If lymph nodes positive, adjuvant chemoradiotherapy
The adjuvant chemotherapy is platinum-based

Stage 2/Limited Stage

Not curative
Early chemoradiotherapy

Stage 3 or 4/Extensive Stage

Not curative
Chemotherapy extends median survival from 3 months to 8 to 13 months
Prophylactic cranial irradiation

@@ Line 1: / Line 1: @@
-== Staging (TMN) ==
+==Staging==
+===TMN===
-* Stage 1: a single lesion ≤3 cm with no lymphadenopathy
+*Stage 1: a single lesion ≤3 cm with no lymphadenopathy
-* Stage 2: ipsilateral lymph nodes and mediastinum
+*Stage 2: ipsilateral lymph nodes and mediastinum
-* Stage 3: contralateral lymph nodes and metastases
+*Stage 3: contralateral lymph nodes and metastases
-* Stage 4: distant metastases
+*Stage 4: distant metastases
-== Staging (VALSG) ==
+===VALSG===
-* ''Limited stage:'' disease confined to ipsilateral lung, lymph nodes, and mediastinum, which can be contained within one radiotherapy window
+*''Limited stage:'' disease confined to ipsilateral lung, lymph nodes, and mediastinum, which can be contained within one radiotherapy window
-* ''Extensive stage:'' metastasis to contralateral lung, contralateral lymph nodes, or distant sites
+*''Extensive stage:'' metastasis to contralateral lung, contralateral lymph nodes, or distant sites
-== Management ==
+==Management==
-=== Stage 1 ===
+===Stage 1===
-* Potentially curative
+*Potentially curative
-* Surgical resection
+*Surgical resection
-** If lymph nodes negative, adjuvant chemotherapy
+**If lymph nodes negative, adjuvant chemotherapy
-** If lymph nodes positive, adjuvant chemoradiotherapy
+**If lymph nodes positive, adjuvant chemoradiotherapy
-* The adjuvant chemotherapy is platinum-based
+*The adjuvant chemotherapy is platinum-based
-=== Stage 2/Limited Stage ===
+===Stage 2/Limited Stage===
-* Not curative
+*Not curative
-* Early chemoradiotherapy
+*Early chemoradiotherapy
-=== Stage 3 or 4/Extensive Stage ===
+===Stage 3 or 4/Extensive Stage===
-* Not curative
+*Not curative
-* Chemotherapy extends median survival from 3 months to 8 to 13 months
+*Chemotherapy extends median survival from 3 months to 8 to 13 months
-* Prophylactic cranial irradiation
+*Prophylactic cranial irradiation
 [[Category:Respirology]]