Rickettsia typhi: Difference between revisions
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Rickettsia typhi
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==Background== |
==Background== |
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| − | *Causes '''murine typhus''' |
+ | *Causes '''murine typhus''', '''flea-borne typhus''', or '''endemic typhus''' |
===Microbiology=== |
===Microbiology=== |
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===Epidemiology=== |
===Epidemiology=== |
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| − | *Flea vector (''[[Vector::Xenopsylla cheopis]]'') with a rat reservoirs ([[Rattus species|''Rattus'' |
+ | *Flea vector (''[[Vector::Xenopsylla cheopis]]'') with a rat reservoirs ([[Rattus species|''Rattus'']]) |
| − | **Also, cat flea vector ([[Vector::Ctenocephalides felis |
+ | **Also, cat flea vector ([[Vector::Ctenocephalides felis]]) in southern US |
**Possibly opossums as reservoirs |
**Possibly opossums as reservoirs |
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*Worldwide distribution |
*Worldwide distribution |
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*[[Causes::Fever]], [[Causes::headache]], [[Causes::nausea]] and [[Causes::vomiting]] are common, as well as [[Causes::myalgias]] |
*[[Causes::Fever]], [[Causes::headache]], [[Causes::nausea]] and [[Causes::vomiting]] are common, as well as [[Causes::myalgias]] |
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*[[Causes::Rash]] develops over the course in about 50% |
*[[Causes::Rash]] develops over the course in about 50% |
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| − | **Usually described as [[Causes::macular rash| |
+ | **Usually described as [[Causes::macular rash|macular]] or [[Causes::maculopapular rash]], sometimes with [[Causes::petechiae]] |
**On trunk, but can involve extremities |
**On trunk, but can involve extremities |
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**Rarely on palms and soles |
**Rarely on palms and soles |
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*CSF shows [[Causes::aseptic meningitis]] |
*CSF shows [[Causes::aseptic meningitis]] |
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*1 to 4% mortality |
*1 to 4% mortality |
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| − | *Sort of like a milder version of '' |
+ | *Sort of like a milder version of ''[[Rickettsia prowazekii]]'' |
==Diagnosis== |
==Diagnosis== |
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Latest revision as of 09:46, 9 February 2022
Background
- Causes murine typhus, flea-borne typhus, or endemic typhus
Microbiology
- Flea-borne Gram-negative intracellular bacterium
Life Cycle
- Flea bites, flea poops, feces get rubbed into the bite wound
- Flea acquires infection from feeding on a rickettsemic host
Epidemiology
- Flea vector (Xenopsylla cheopis) with a rat reservoirs (Rattus)
- Also, cat flea vector (Ctenocephalides felis) in southern US
- Possibly opossums as reservoirs
- Worldwide distribution
- In the US, most cases are in southern Texas and California
Clinical Manifestations
- Incubation period of 1 to 2 weeks, but rarely remember flea exposure
- Fever, headache, nausea and vomiting are common, as well as myalgias
- Rash develops over the course in about 50%
- Usually described as macular or maculopapular rash, sometimes with petechiae
- On trunk, but can involve extremities
- Rarely on palms and soles
- May have leukopenia and thrombocytopenia early in the course
- Elevated AST is common, as well as other liver enzymes
- Further nausea/vomiting and anorexia, cough, and hepatosplenomegaly may all develop
- Neurologic complications include confusion, seizures, and ataxia
- They often develop hypoalbuminemia and electrolyte abnormalities such as hyponatremia and hypocalcemia
- CSF shows aseptic meningitis
- 1 to 4% mortality
- Sort of like a milder version of Rickettsia prowazekii
Diagnosis
- Based on acute and convalescent serology looking for a 4-fold risk after about 4 weeks
- Possibly PCR of skin biopsy
Management
- doxycycline 100 mg PO bid for 7 to 10 days
- Should be treated empirically, since cannot confirm diagnosis quickly
