Renal disease in HIV: Difference between revisions
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m (Text replacement - "== Presentation" to "== Clinical Manifestations") |
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| − | = Differential Diagnosis = |
+ | == Differential Diagnosis == |
* Infection-related |
* Infection-related |
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** Indinavir, sulfadiazine, and IV acyclovir: tubular obstruction from crystals |
** Indinavir, sulfadiazine, and IV acyclovir: tubular obstruction from crystals |
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| − | = HIV-associated nephropathy (HIVAN) = |
+ | == HIV-associated nephropathy (HIVAN) == |
| + | === Clinical Manifestations === |
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| − | == Presentation == |
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* Proteinuria, mild creatinine elevation, normal-seized echogenic kidneys on renal US |
* Proteinuria, mild creatinine elevation, normal-seized echogenic kidneys on renal US |
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* Biopsy shows FSGS |
* Biopsy shows FSGS |
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| − | == Management == |
+ | === Management === |
* Treat the HIV with usual therapy |
* Treat the HIV with usual therapy |
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Latest revision as of 06:56, 2 August 2020
Differential Diagnosis
- Infection-related
- HIV-associated nephropathy (HIVAN)
- Immune complex-mediated glomerular disease
- Coinfection with hepatitis B or C
- Treatment-related
- Tenofovir: Fanconi syndrome
- Pantamidine, foscarnet, and aminoglycosides: ATN
- Indinavir, sulfadiazine, and IV acyclovir: tubular obstruction from crystals
HIV-associated nephropathy (HIVAN)
Clinical Manifestations
- Proteinuria, mild creatinine elevation, normal-seized echogenic kidneys on renal US
- Usually have a detectable viral load, and decreased CD4 <200
- Biopsy shows FSGS
Management
- Treat the HIV with usual therapy
- Steroids for 8 to 12 weeks
- ACEi/ARB as tolerated
