Quinine: Difference between revisions
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(Created page with "== Background == * The main indication is for treatment of malaria * Used off-label (and possibly dangerously and ineffectively) as a treatment for nocturnal leg cramps == Safety == === Adverse Effects === * '''Cinchonism''': tinnitus, high-tone hearing loss, photophobia and other visual disturbances, dysphoria, headache, nausea, vomiting, sweating, dizziness and postural hypotension * Hypoglycemia, from pancreatic β cell stimulation * Hypotension, usually from...") |
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* The main indication is for treatment of [[malaria]] |
* The main indication is for treatment of [[malaria]] |
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| + | * Used off-label as a treatment for nocturnal leg cramps<ref>Hogan DB. Quinine: not a safe drug for treating nocturnal leg cramps. CMAJ. 2015 Mar 3;187(4):237-238. doi: [https://doi.org/10.1503/cmaj.150044 10.1503/cmaj.150044]. Epub 2015 Jan 26. PMID: 25623647; PMCID: PMC4347765.</ref> |
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| − | * Used off-label (and possibly dangerously and ineffectively) as a treatment for nocturnal leg cramps |
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== Safety == |
== Safety == |
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Latest revision as of 11:41, 29 April 2023
Background
- The main indication is for treatment of malaria
- Used off-label as a treatment for nocturnal leg cramps[1]
Safety
Adverse Effects
- Cinchonism: tinnitus, high-tone hearing loss, photophobia and other visual disturbances, dysphoria, headache, nausea, vomiting, sweating, dizziness and postural hypotension
- Hypoglycemia, from pancreatic β cell stimulation
- Hypotension, usually from IV infusion
- Hearing and visual disturbances, including irreversible loss
- Gastrointestinal symptoms
- Cutaneous effects
- Mild QT prolongation (rare unless plasma levels are elevated) and arrhythmias
- Hemolysis (in patients with G6PD deficiency or with hypersensitivity)
- ↑ Hogan DB. Quinine: not a safe drug for treating nocturnal leg cramps. CMAJ. 2015 Mar 3;187(4):237-238. doi: 10.1503/cmaj.150044. Epub 2015 Jan 26. PMID: 25623647; PMCID: PMC4347765.
