Pyoderma gangrenosum
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Revision as of 18:26, 9 December 2022 by Aidan (talk | contribs) (Created page with "== Diagnosis == === Diagnostic Criteria<ref>Maverakis E, Ma C, Shinkai K, Fiorentino D, Callen JP, Wollina U, Marzano AV, Wallach D, Kim K, Schadt C, Ormerod A, Fung MA, Steel A, Patel F, Qin R, Craig F, Williams HC, Powell F, Merleev A, Cheng MY. Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts. JAMA Dermatol. 2018 Apr 1;154(4):461-466. doi: [https://doi.org/10.1001/jamadermatol.2017.5980 10.1001/jamadermatol.2017.5980...")
Diagnosis
Diagnostic Criteria[1]
- Major criterion:
- Biopsy of ulcer edge demonstrating a neutrophilic infiltrate
- Minor criteria:
- Exclusion of infection
- Pathergy
- Personal history of inflammatory bowel disease or inflammatory arthritis
- History of papule, pustule, or vesicle that rapidly ulcerated
- Peripheral erythema, undermining border, and tenderness at site of ulceration
- Multiple ulcerations (at least one occurring on an anterior lower leg)
- Cribriform or "wrinkled paper" scar(s) at sites of healed ulcers
- Decrease in ulcer size within one month of initiating immunosuppressive medications
- Interpretation:
- Positive if at the major criterion and at least four minor criteria are present
- ↑ Maverakis E, Ma C, Shinkai K, Fiorentino D, Callen JP, Wollina U, Marzano AV, Wallach D, Kim K, Schadt C, Ormerod A, Fung MA, Steel A, Patel F, Qin R, Craig F, Williams HC, Powell F, Merleev A, Cheng MY. Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts. JAMA Dermatol. 2018 Apr 1;154(4):461-466. doi: 10.1001/jamadermatol.2017.5980. PMID: 29450466.
