Prosthetic joint infection: Difference between revisions
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[[Category:Bone and joint infections]] |
[[Category:Bone and joint infections]] |
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[[Category:Infectious diseases]] |
[[Category:Infectious diseases]] |
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| + | == Background == |
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| + | |||
| + | === Microbiology === |
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| + | |||
| + | * Hip and knee |
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| + | ** Early (<3 months): [[Staphylococcus aureus]] (38%), aerobic [[Gram-negative bacilli]] (24%), [[coagulase-negative staphylococci]] (22%), [[Enterococcus species]] (10%), and [[Streptococcus species]] (4%), [[anaerobes]] including [[Cutibacterium acnes]] (3%), culture-negative (10%); 31% are polymicrobial |
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| + | ** Overall: [[Staphylococcus aureus]] (27%), [[coagulase-negative staphylococci]] (27%), aerobic [[Gram-negative bacilli]] (9%), [[Streptococcus species]] (8%), [[anaerobes]] including [[Cutibacterium acnes]] (4%), [[Enterococcus species]] (3%), culture-negative (14%); 15% are polymicrobial |
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| + | * Shoulder: [[coagulase-negative staphylococci]] (42%), [[Cutibacterium acnes]] (24%), [[Staphylococcus aureus]] (18%), aerobic [[Gram-negative bacilli]] (10%), others, culture-negative (15%); polymicrobial in 16% |
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| + | * Elbow: [[Staphylococcus aureus]] (42%), [[coagulase-negative staphylococci]] (41%), others, culture-negative (5%); polymicrobial in 3% |
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| + | |||
| + | === Epidemiology === |
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| + | |||
| + | * Complicates about 2% of [[arthroplasty]] |
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| + | === Pathophysiology === |
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| + | * Bacteria grown on the prosthesis in a biofilm, making it resistant to medical management |
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| + | |||
| + | == Further Reading == |
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| + | |||
| + | * Prosthetic Joint Infection. ''Clin Micro Rev''. 2014;27(2):302-345. doi: [https://doi.org/10.1128/CMR.00111-13 10.1128/CMR.00111-13] |
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Revision as of 19:52, 8 July 2020
Background
Microbiology
- Hip and knee
- Early (<3 months): Staphylococcus aureus (38%), aerobic Gram-negative bacilli (24%), coagulase-negative staphylococci (22%), Enterococcus species (10%), and Streptococcus species (4%), anaerobes including Cutibacterium acnes (3%), culture-negative (10%); 31% are polymicrobial
- Overall: Staphylococcus aureus (27%), coagulase-negative staphylococci (27%), aerobic Gram-negative bacilli (9%), Streptococcus species (8%), anaerobes including Cutibacterium acnes (4%), Enterococcus species (3%), culture-negative (14%); 15% are polymicrobial
- Shoulder: coagulase-negative staphylococci (42%), Cutibacterium acnes (24%), Staphylococcus aureus (18%), aerobic Gram-negative bacilli (10%), others, culture-negative (15%); polymicrobial in 16%
- Elbow: Staphylococcus aureus (42%), coagulase-negative staphylococci (41%), others, culture-negative (5%); polymicrobial in 3%
Epidemiology
- Complicates about 2% of arthroplasty
Pathophysiology
- Bacteria grown on the prosthesis in a biofilm, making it resistant to medical management
Further Reading
- Prosthetic Joint Infection. Clin Micro Rev. 2014;27(2):302-345. doi: 10.1128/CMR.00111-13
References
- ^ Louis Bernard, Cédric Arvieux, Benoit Brunschweiler, Sophie Touchais, Séverine Ansart, Jean-Pierre Bru, Eric Oziol, Cyril Boeri, Guillaume Gras, Jérôme Druon, Philippe Rosset, Eric Senneville, Houcine Bentayeb, Damien Bouhour, Gwenaël Le Moal, Jocelyn Michon, Hugues Aumaître, Emmanuel Forestier, Jean-Michel Laffosse, Thierry Begué, Catherine Chirouze, Fréderic-Antoine Dauchy, Edouard Devaud, Benoît Martha, Denis Burgot, David Boutoille, Eric Stindel, Aurélien Dinh, Pascale Bemer, Bruno Giraudeau, Bertrand Issartel, Agnès Caille. Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection. New England Journal of Medicine. 2021;384(21):1991-2001. doi:10.1056/nejmoa2020198.
- ^ Joshua S Davis, Sarah Metcalf, Benjamin Clark, J Owen Robinson, Paul Huggan, Chris Luey, Stephen McBride, Craig Aboltins, Renjy Nelson, David Campbell, L Bogdan Solomon, Kellie Schneider, Mark R Loewenthal, Piers Yates, Eugene Athan, Darcie Cooper, Babak Rad, Tony Allworth, Alistair Reid, Kerry Read, Peter Leung, Archana Sud, Vana Nagendra, Roy Chean, Chris Lemoh, Nora Mutalima, Ton Tran, Kate Grimwade, Marjoree Sehu, Davis Looke, Adrienne Torda, Thi Aung, Steven Graves, David L Paterson, Laurens Manning. Predictors of treatment success following peri-prosthetic joint infection: 24-month follow up from a multi-center prospective observational cohort study of 653 patients. Open Forum Infectious Diseases. 2022. doi:10.1093/ofid/ofac048.
- ^ Werner Zimmerli, Parham Sendi. Role of Rifampin against Staphylococcal Biofilm InfectionsIn Vitro, in Animal Models, and in Orthopedic-Device-Related Infections. Antimicrobial Agents and Chemotherapy. 2018;63(2):e01746-18. doi:10.1128/aac.01746-18.
- ^ James B. Doub, Emily L. Heil, Afua Ntem-Mensah, Renaldo Neeley, Patrick R. Ching. Rifabutin Use in Staphylococcus Biofilm Infections: A Case Series. Antibiotics. 2020;9(6):326. doi:10.3390/antibiotics9060326.
