Posaconazole: Difference between revisions

Revision as of 12:00, 19 January 2021

Measure trough 7 days after starting or adjusting dose, or adjusting interacting medications, or concerns of poor adherence or absorption
For prophylaxis, target trough >0.7 mg/L, or random level 0.35 mg/L 48 h after starting therapy
For treatment, target trough >1 mg/L

@@ Line 1: / Line 1: @@
-== Therapeutic Drug Monitoring ==
+==Therapeutic Drug Monitoring==
-* Measure trough 7 days after starting or adjusting dose, or adjusting interacting medications, or concerns of poor adherence or absorption
-* For prophylaxis, target trough >0.7 mg/L, or random level 0.35 mg/L 48 h after starting therapy
-* For treatment, target trough >1 mg/L
+*Measure trough 7 days after starting or adjusting dose, or adjusting interacting medications, or concerns of poor adherence or absorption
+*For prophylaxis, target trough >0.7 mg/L, or random level 0.35 mg/L 48 h after starting therapy
+*For treatment, target trough >1 mg/L
+=== Epidemiologic Cutoff Values ===
+{| class="wikitable"
+!Species
+!ECV (mcg/mL)
+|-
+|C. albicans
+|0.06
+|-
+|C. glabrata
+|2
+|-
+|C. parapsilosis
+|0.25
+|-
+|C. tropicalis
+|0.12
+|-
+|C. krusei
+|0.5
+|-
+|C. lusitaniae
+|0.12
+|-
+|C. guilliermondii
+|0.5
+|-
+|C. kefyr
+|0.25
+|}
 [[Category:Triazoles]]