Paracoccidioides brasiliensis: Difference between revisions
From IDWiki
Paracoccidioides brasiliensis
m (Aidan moved page Dimorphic to Paracoccidioides brasiliensis without leaving a redirect) |
No edit summary |
||
| Line 1: | Line 1: | ||
| ⚫ | |||
| ⚫ | |||
| − | |||
| ⚫ | |||
* Dimorphic fungus with four phylogenetic lineages |
* Dimorphic fungus with four phylogenetic lineages |
||
| Line 7: | Line 5: | ||
* '''Mariner's wheel''' of budding conidia |
* '''Mariner's wheel''' of budding conidia |
||
| − | + | = Epidemiology = |
|
* South and Central America, with Brazil being the largest endemic country |
* South and Central America, with Brazil being the largest endemic country |
||
* Has been isolated from the feces of bats (''Artibeus lituratus'') and from internal organs of the nine-banded armadillo |
* Has been isolated from the feces of bats (''Artibeus lituratus'') and from internal organs of the nine-banded armadillo |
||
| − | + | = Clinical Presentation = |
|
* Usually self-limited pulmonary infection |
* Usually self-limited pulmonary infection |
||
| Line 23: | Line 21: | ||
* However, may remain latent following infection, and reactivate later as pulmonary or disseminated disease |
* However, may remain latent following infection, and reactivate later as pulmonary or disseminated disease |
||
| − | + | = Diagnosis = |
|
* Serology |
* Serology |
||
| Line 29: | Line 27: | ||
** Antigen |
** Antigen |
||
| − | + | = Management = |
|
* Itraconazole 200 to 400 mg/day for 9 to 12 months |
* Itraconazole 200 to 400 mg/day for 9 to 12 months |
||
* If severe, consider amphotericin 1mg/kg/day |
* If severe, consider amphotericin 1mg/kg/day |
||
* ?Septra |
* ?Septra |
||
| + | |||
| ⚫ | |||
| + | [[Category:Fungi]] |
||
Revision as of 19:20, 14 August 2019
Microbiology
- Dimorphic fungus with four phylogenetic lineages
- Disease is caused by P. brasiliensis and P. lutzii (newly discovered)
- Mariner's wheel of budding conidia
Epidemiology
- South and Central America, with Brazil being the largest endemic country
- Has been isolated from the feces of bats (Artibeus lituratus) and from internal organs of the nine-banded armadillo
Clinical Presentation
- Usually self-limited pulmonary infection
- Can cause acute/subacute pulmonary infection in children, adolescents, and immunocompromised individuals
- Fever, weight loss, lymphadenopathy, and hepatosplenomegaly
- Half have skin and mucosal lesions
- Can cause chronic disease in adults
- Pulmonary infiltrates on CXR
- Adrenal lesions with insufficiency are common
- However, may remain latent following infection, and reactivate later as pulmonary or disseminated disease
Diagnosis
- Serology
- Antibodies
- Antigen
Management
- Itraconazole 200 to 400 mg/day for 9 to 12 months
- If severe, consider amphotericin 1mg/kg/day
- ?Septra
