Oseltamivir: Difference between revisions

Latest revision as of 10:52, 31 July 2020

Background

Mechanism of Action

Inhibits viral neuraminidase, which is required for virion release after budding

Dose

Adults

Influenza (treatment): 75 mg PO bid for 5 days, started within 48 hours of illness onset
Influenza (prophylaxis): 75 mg PO daily

Renal Dosing

Indication	CrCl >60	CrCl >30 to 60 mL/min	CrCl >10 to 30 mL/min	IHD	CAPD	CRRT
Influenza (treatment)	Usual dose	30 mg PO bid	30 mg PO daily	30 (low-flux) to 75 (high-flux) mg PO after dialysis	30 mg PO once	30 mg once daily
Influenza (prophylaxis)	Usual dose	30 mg PO daily	30 mg PO every other day	30 mg PO after every other dialysis	30 mg PO weekly	Unclear

Hepatic Dosing

No dose adjustment needed

Pediatric

Influenza (treatment):
- Infants ≤8 months: 3 mg/kg/dose PO bid
- Infants ≥9 months: 3.5 mg/kg/dose PO bid
- Children ≤15 kg: 30 mg PO bid
- Children >15 to 23 kg: 45 mg PO bid
- Children >23 to 40 kg: 60 mg PO bid
- Children & adolescents >40 kg: 75 mg PO bid (adult dose)
- Duration 5 days, started within 48 hours of illness onset
Influenza (prophylaxis):
- Same doses as above, used once daily instead of bid

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Mechanism of Action ===
+===Mechanism of Action===
-* Inhibits viral neuraminidase
+*Inhibits viral neuraminidase, which is required for virion release after budding
-== Dose ==
-=== Adults ===
-* Influenza (treatment): 75 mg PO bid
-* Influenza (prophylaxis): 75 mg PO daily
+==Dose==
-==== Renal Dosing ====
+===Adults===
-{| style="wikitable"
-! Indication
+*Influenza (treatment): 75 mg PO bid for 5 days, started within 48 hours of illness onset
-! CrCl >60
+*Influenza (prophylaxis): 75 mg PO daily
-! CrCl >30 to 60 mL/min
-! CrCl >10 to 30 mL/min
+====Renal Dosing====
-! IHD
+{| class="wikitable"
+!Indication
+!CrCl >60
+!CrCl >30 to 60 mL/min
+!CrCl >10 to 30 mL/min
+!IHD
+!CAPD
+!CRRT
 |-
-| Influenza (treatment)
+|Influenza (treatment)
-| Usual dose
+|Usual dose
-| 30 mg PO bid
+|30 mg PO bid
-| 30 mg PO daily
+|30 mg PO daily
-| 30 (low-flux) to 75 (high-flux) mg PO after dialysis
+|30 (low-flux) to 75 (high-flux) mg PO after dialysis
+|30 mg PO once
+|30 mg once daily
 |-
-| Influenza (prophylaxis)
+|Influenza (prophylaxis)
-| Usual dose
+|Usual dose
-| 30 mg PO daily
+|30 mg PO daily
-| 30 mg PO every other day
+|30 mg PO every other day
-| 30 mg PO after every other dialysis
+|30 mg PO after every other dialysis
+|30 mg PO weekly
+|Unclear
 |}
+==== Hepatic Dosing ====
+* No dose adjustment needed
+===Pediatric===
+*Influenza (treatment):
+**Infants ≤8 months: 3 mg/kg/dose PO bid
+**Infants ≥9 months: 3.5 mg/kg/dose PO bid
+**Children ≤15 kg: 30 mg PO bid
+**Children >15 to 23 kg: 45 mg PO bid
+**Children >23 to 40 kg: 60 mg PO bid
+**Children & adolescents >40 kg: 75 mg PO bid (adult dose)
+**Duration 5 days, started within 48 hours of illness onset
+*Influenza (prophylaxis):
+**Same doses as above, used once daily instead of bid
 [[Category:Antivirals]]