Oseltamivir: Difference between revisions

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===Mechanism of Action===
 
===Mechanism of Action===
   
*Inhibits viral neuraminidase
+
*Inhibits viral neuraminidase, which is required for virion release after budding
   
 
==Dose==
 
==Dose==
 
===Adults===
 
===Adults===
   
*Influenza (treatment): 75 mg PO bid
+
*Influenza (treatment): 75 mg PO bid for 5 days, started within 48 hours of illness onset
 
*Influenza (prophylaxis): 75 mg PO daily
 
*Influenza (prophylaxis): 75 mg PO daily
   
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!CrCl >10 to 30 mL/min
 
!CrCl >10 to 30 mL/min
 
!IHD
 
!IHD
  +
!CAPD
  +
!CRRT
 
|-
 
|-
 
|Influenza (treatment)
 
|Influenza (treatment)
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|30 mg PO daily
 
|30 mg PO daily
 
|30 (low-flux) to 75 (high-flux) mg PO after dialysis
 
|30 (low-flux) to 75 (high-flux) mg PO after dialysis
  +
|30 mg PO once
  +
|30 mg once daily
 
|-
 
|-
 
|Influenza (prophylaxis)
 
|Influenza (prophylaxis)
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|30 mg PO every other day
 
|30 mg PO every other day
 
|30 mg PO after every other dialysis
 
|30 mg PO after every other dialysis
  +
|30 mg PO weekly
  +
|Unclear
 
|}
 
|}
  +
  +
=== Pediatric ===
  +
  +
* Influenza (treatment):
  +
** Infants ≤8 months: 3 mg/kg/dose PO bid
  +
** Infants ≥9 months: 3.5 mg/kg/dose PO bid
  +
** Children ≤15 kg: 30 mg PO bid
  +
** Children >15 to 23 kg: 45 mg PO bid
  +
** Children >23 to 40 kg: 60 mg PO bid
  +
** Children & adolescents >40 kg: 75 mg PO bid (adult dose)
  +
** Duration 5 days, started within 48 hours of illness onset
  +
* Influenza (prophylaxis):
  +
** Same doses as above, used once daily instead of bid
   
 
[[Category:Antivirals]]
 
[[Category:Antivirals]]

Revision as of 10:51, 31 July 2020

Background

Mechanism of Action

  • Inhibits viral neuraminidase, which is required for virion release after budding

Dose

Adults

  • Influenza (treatment): 75 mg PO bid for 5 days, started within 48 hours of illness onset
  • Influenza (prophylaxis): 75 mg PO daily

Renal Dosing

Indication CrCl >60 CrCl >30 to 60 mL/min CrCl >10 to 30 mL/min IHD CAPD CRRT
Influenza (treatment) Usual dose 30 mg PO bid 30 mg PO daily 30 (low-flux) to 75 (high-flux) mg PO after dialysis 30 mg PO once 30 mg once daily
Influenza (prophylaxis) Usual dose 30 mg PO daily 30 mg PO every other day 30 mg PO after every other dialysis 30 mg PO weekly Unclear

Pediatric

  • Influenza (treatment):
    • Infants ≤8 months: 3 mg/kg/dose PO bid
    • Infants ≥9 months: 3.5 mg/kg/dose PO bid
    • Children ≤15 kg: 30 mg PO bid
    • Children >15 to 23 kg: 45 mg PO bid
    • Children >23 to 40 kg: 60 mg PO bid
    • Children & adolescents >40 kg: 75 mg PO bid (adult dose)
    • Duration 5 days, started within 48 hours of illness onset
  • Influenza (prophylaxis):
    • Same doses as above, used once daily instead of bid