Opioids: Difference between revisions
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|[[Oxycodone]] |
|[[Oxycodone]] |
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|1.5 |
|1.5 |
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| + | |— |
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| + | |- |
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| + | |[[Methadone]] |
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| + | |3 |
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|— |
|— |
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| − | === |
+ | ===Fentanyl=== |
{| class="wikitable" |
{| class="wikitable" |
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!Fentanyl mcg/h |
!Fentanyl mcg/h |
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*IV is essentially twice as strong as PO |
*IV is essentially twice as strong as PO |
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| + | == Safety == |
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| + | |||
| + | === Adverse Events === |
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| + | {| class="wikitable" |
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| + | ! |
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| + | !Common |
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| + | !Occasional |
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| + | !Rare |
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| + | |- |
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| + | |Gastrointestinal |
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| + | |nausea, vomiting, constipation |
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| + | |delayed gastric emptying |
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| + | |biliary coli |
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| + | |- |
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| + | |Neurological |
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| + | |sedation, drowsiness, cognitive dysfunction |
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| + | |hallucinations, mood disturbance, anxiety, myoclonus |
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| + | |delirium, seizure, addiction |
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| + | |- |
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| + | |Respiratory |
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| + | |inhibition of cough reflex |
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| + | |dry mouth, bronchospasm |
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| + | |respiratory depression, non-cardiac pulmonary edema |
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| + | |- |
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| + | |Others |
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| + | |miosis |
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| + | |pruritus, muscle rigidity |
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| + | |hyperalgesia, allodynia, tolerance, physical dependence |
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| + | |} |
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[[Category:Addiction medicine]] |
[[Category:Addiction medicine]] |
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[[Category:Anaesthesia]] |
[[Category:Anaesthesia]] |
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Latest revision as of 11:52, 7 May 2021
Background
- Class of analgesic medications that act primarily on the μ-opioid receptor
Morphine Milligram Equivalent Dose
| Drug | MME per mg PO | MME per mg IV/SC |
|---|---|---|
| Meperidine | 0.1 | — |
| Codeine | 0.15 | — |
| Morphine | 1 | 2 |
| Oxycodone | 1.5 | — |
| Methadone | 3 | — |
| Hydromorphone | 5 | 10 |
| Fentanyl | 200 MME per 50 mcg/h transdermal | |
Fentanyl
| Fentanyl mcg/h | MME |
|---|---|
| 25 | 60-134 |
| 37 | 135-179 |
| 50 | 180-224 |
| 62 | 225-269 |
| 75 | 270-314 |
| 87 | 315-359 |
| 100 | 360-404 |
- IV is essentially twice as strong as PO
Safety
Adverse Events
| Common | Occasional | Rare | |
|---|---|---|---|
| Gastrointestinal | nausea, vomiting, constipation | delayed gastric emptying | biliary coli |
| Neurological | sedation, drowsiness, cognitive dysfunction | hallucinations, mood disturbance, anxiety, myoclonus | delirium, seizure, addiction |
| Respiratory | inhibition of cough reflex | dry mouth, bronchospasm | respiratory depression, non-cardiac pulmonary edema |
| Others | miosis | pruritus, muscle rigidity | hyperalgesia, allodynia, tolerance, physical dependence |
