Normal pressure hydrocephalus: Difference between revisions

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m (Text replacement - "Clinical Presentation" to "Clinical Manifestations")
 
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* Vascular dementia
 
* Vascular dementia
   
== Clinical Presentation ==
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== Clinical Manifestations ==
   
 
* "Wobbly, wet, and wacky"
 
* "Wobbly, wet, and wacky"

Latest revision as of 22:07, 21 July 2020

Differential Diagnosis

  • Dementia with Lewy bodies
  • Parkinson disease dementia
  • Progressive supranuclear palsy
  • Multiple system atrophy
  • Corticobasal syndrome
  • Alzheimer disease
  • Vascular dementia

Clinical Manifestations

  • "Wobbly, wet, and wacky"
  • Presents with gait instability/apraxia ("magnetic gait") progressing over months to years, followed by dementia
    • Cognitive symptoms include psychomotor slowing, decreased attention/concentration, impaired executive function, and apathy
  • Urinary incontinence is common, presenting first as urgency with an inability to reach the bathroom in time, then later progressing to incontinence with apathy
  • There should be no headaches, nausea/vomiting, visual changes, or papilledema

Investigations

  • Should have normal CBC, lytes, creatinine, vit B12, TSH, calcium
  • CT head showing hydrocephalus
  • Lumbar puncture confirming normal pressure

Management

  • High-volume lumbar puncture (30 to 50 mL)
    • If there is improvement in symptoms, consider implanting a ventriculoperitoneal shunt