Multiple endocrine neoplasia type 1

Background

• Also called Wermer syndrome

Clinical Manifestations

• 3 P's: parathyroid, pancreas, and pituitary
• Parathyroid
  • Primary hyperparathyroidism in 80-95% of cases, leading to hypercalcemia
  • Often the presenting complaint
• Pancreas:
  • Endocrine tumours of the pancreas, including gastrinomas (causing Zollinger-Ellison syndrome) and insulinomas (causing hypoglycemia)
  • Often metastatic by the time of diagnosis
• Pituitary
  • Prolactinoma is most common,
  • Can also present with growth-hormone-producing adenomas (causing acromegaly)