Multiple endocrine neoplasia type 1: Difference between revisions
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| + | == Background == |
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| + | * Also called Wermer syndrome |
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| + | == Clinical Manifestations == |
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| + | * 3 P's: parathyroid, pancreas, and pituitary |
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| + | * Parathyroid |
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| + | ** [[Primary hyperparathyroidism]] in 80-95% of cases, leading to [[hypercalcemia]] |
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| + | ** Often the presenting complaint |
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| + | * Pancreas: |
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| + | ** Endocrine tumours of the pancreas, including gastrinomas (causing [[Zollinger-Ellison syndrome]]) and insulinomas (causing hypoglycemia) |
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| + | ** Often metastatic by the time of diagnosis |
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| + | * Pituitary |
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| + | ** [[Prolactinoma]] is most common, |
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| + | ** Can also present with growth-hormone-producing adenomas (causing [[acromegaly]]) |
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| + | [[Category:Endocrinology]] |
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| + | [[Category:Oncology]] |
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Latest revision as of 12:29, 18 February 2021
Background
- Also called Wermer syndrome
Clinical Manifestations
- 3 P's: parathyroid, pancreas, and pituitary
- Parathyroid
- Primary hyperparathyroidism in 80-95% of cases, leading to hypercalcemia
- Often the presenting complaint
- Pancreas:
- Endocrine tumours of the pancreas, including gastrinomas (causing Zollinger-Ellison syndrome) and insulinomas (causing hypoglycemia)
- Often metastatic by the time of diagnosis
- Pituitary
- Prolactinoma is most common,
- Can also present with growth-hormone-producing adenomas (causing acromegaly)
