Mpox virus: Difference between revisions
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+ | ==Background== |
| + | ===Microbiology=== |
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+ | *Monkeypox virus (MPXV) is in the genus ''Orthopoxvirus'' and family ''Poxviridae'' |
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+ | ===Epidemiology=== |
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+ | *Zoonotic disease endemic to west and central Africa |
| − | ** |
+ | **Hosts include non-human primates and prairie dogs, squirrels, and possibly other rodents |
| − | ** |
+ | **Endemic countries include DRC (most common), Liberia, Ivory Coast, Sierra Leone, Nigeria, Benin, Cameroon, Gabon, and South Sudan |
| − | * |
+ | *Human infection is associated with animal trapping, hunting, and skinning, and other exposures to animals including bites, feces, urine, or respiratory droplets |
| − | ** |
+ | **Global outbreaks may happen with the global trafficking in exotic pets |
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+ | *Human-to-human transmission possible, but less than smallpox |
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+ | ==Clinical Manifestations== |
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+ | *Clinically indistinguishible from smallpox, though may have much more pronounced lymphadenopathy |
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+ | *Incubation period about [[Usual incubation period::12 days]] |
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+ | *[[Causes::Fever]], [[Causes::rash]], [[Causes::lymphadenopathy]] (cervical, submandibular, and sublingual) |
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+ | *Mortality 1-10% (per WHO) |
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+ | ==Management== |
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+ | ===Post-exposure prophylaxis=== |
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+ | *??smallpox vaccine?? |
[[Category:Poxviridae]] |
[[Category:Poxviridae]] |
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Revision as of 09:43, 5 August 2020
Background
Microbiology
- Monkeypox virus (MPXV) is in the genus Orthopoxvirus and family Poxviridae
Epidemiology
- Zoonotic disease endemic to west and central Africa
- Hosts include non-human primates and prairie dogs, squirrels, and possibly other rodents
- Endemic countries include DRC (most common), Liberia, Ivory Coast, Sierra Leone, Nigeria, Benin, Cameroon, Gabon, and South Sudan
- Human infection is associated with animal trapping, hunting, and skinning, and other exposures to animals including bites, feces, urine, or respiratory droplets
- Global outbreaks may happen with the global trafficking in exotic pets
- Human-to-human transmission possible, but less than smallpox
Clinical Manifestations
- Clinically indistinguishible from smallpox, though may have much more pronounced lymphadenopathy
- Incubation period about 12 days
- Fever, rash, lymphadenopathy (cervical, submandibular, and sublingual)
- Mortality 1-10% (per WHO)
Management
Post-exposure prophylaxis
- ??smallpox vaccine??
