Macrolides: Difference between revisions

Latest revision as of 06:19, 28 September 2020

Generally considered to be bacteriostatic
Mostly time-dependent killing with prolonged post-antibiotic effect, efficacy best predicted by AUC₂₄:MIC
- However, azithromycin and other ketolides have concentration-dependent bactericidal action with prolonged post-antibiotic effect

@@ Line 1: / Line 1: @@
+== Background ==
-* Binds the 23S subunit of the 50S ribosome, blocking protein synthesis
-* Generally considered to be bacteriostatic
-== Members ==
+=== Mechanism of Action ===
+*Binds the 23S subunit of the 50S ribosome, blocking protein synthesis
-* [[Azithromycin]]
-* [[Clarithromycin]]
+=== Pharmacokinetics and Pharmacodynamics ===
-* [[Erythromycin]]
-* [[Fidaxomicin]]
+*Generally considered to be bacteriostatic
-* [[Spiramycin]]
+*Mostly time-dependent killing with prolonged post-antibiotic effect, efficacy best predicted by AUC<sub>24</sub>:MIC
+**However, [[azithromycin]] and other ketolides have concentration-dependent bactericidal action with prolonged post-antibiotic effect
+==Members==
+*[[Azithromycin]]
+*[[Clarithromycin]]
+*[[Erythromycin]]
+*[[Fidaxomicin]]
+*[[Spiramycin]]
 [[Category:Antibiotics]]