Lymphoplasmacytic lymphoma: Difference between revisions

Latest revision as of 14:03, 26 July 2023

Low-grade B-cell neoplasm frequently causing an IgM gammopathy (at which point it is called Waldenström macroglobulinemia)

Depends on underlying health and age
Treatment only indicated if symptoms progressing
From most to least effective (and most to least side effects):
- RCP: rituximab, cyclophosphamide, prednisone (or dexamethasone for DRC)
- BR: bendamustine/rituximab
- Chlorambucil/Obinutuzumab
- Ibrutinib
Before chemotherapy, screen for hepatitis B +/- TB/Strongyloides

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 == Definition ==
-* Low-grade B-cell neoplasm frequently causing an IgM gammopathy (at which point it is called Waldenstrom's macroglobulinemia)
+* Low-grade B-cell neoplasm frequently causing an IgM gammopathy (at which point it is called [[Waldenström macroglobulinemia]])
 == Investigations ==
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 * Hyperviscosity, including neurological symptoms
-* Peripheral neuropathy
+* [[Peripheral neuropathy]]
 * Lymphadenopathy, organomegaly, cytopenia
 * Constitutional symptoms
@@ Line 19: / Line 19: @@
 * Treatment only indicated if symptoms progressing
 * From most to least effective (and most to least side effects):
-** RCP: rituximab, cyclophosphamide, prednisone (or dexamethasone for DRC)
+** [[RCP]]: [[rituximab]], [[cyclophosphamide]], [[prednisone]] (or [[dexamethasone]] for [[DRC]])
-** BR: bendamustine/rituximab
+** [[BR]]: [[bendamustine]]/[[rituximab]]
-** Chlorambucil/Obinutuzumab
+** [[Chlorambucil]]/[[Obinutuzumab]]
-** Ibrutinib
+** [[Ibrutinib]]
-* Before chemotherapy, screen for hepatitis B +/- TB/Strongy
+* Before chemotherapy, screen for [[hepatitis B]] +/- [[TB]]/[[Strongyloides]]
 [[Category:Hematology]]