Letermovir: Difference between revisions
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+ | == Background == |
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− | * Antiviral |
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− | * Oral and intravenous |
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+ | === Mechanism of Action === |
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+ | *Antiviral that targets subunit 2 of the viral terminase complex (UL56) in [[cytomegalovirus]] |
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+ | === Spectrum of Activity === |
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+ | *No activity against [[HSV]] or [[VZV]] |
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+ | == Dosing == |
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+ | * Letermovir 480 mg IV/PO q24h, infused over 1 hour |
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+ | * If concomitant [[cyclosporine]], decrease dose to 240 mg IV/PO q24h |
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+ | === Renal Dosing === |
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+ | == Safety == |
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+ | === Adverse Drug Reaction === |
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+ | * Nausea, vomiting, diarrhea, cough, headache, peripheral edema |
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+ | === Drug-Drug Interactions === |
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+ | *Decreases concentration of [[voriconazole]] |
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+ | *Concentration of letermovir is increased by [[atorvastatin]], [[sirolimus]], and [[tacrolimus]] |
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[[Category:Antivirals]] |
[[Category:Antivirals]] |
Latest revision as of 06:43, 3 September 2020
Background
Mechanism of Action
- Antiviral that targets subunit 2 of the viral terminase complex (UL56) in cytomegalovirus
Spectrum of Activity
- Indications: Cytomegalovirus
- No activity against HSV or VZV
Dosing
- Letermovir 480 mg IV/PO q24h, infused over 1 hour
- If concomitant cyclosporine, decrease dose to 240 mg IV/PO q24h
Renal Dosing
- No dose adjustment needed as long as CrCl >10 mL/min
Safety
Adverse Drug Reaction
- Nausea, vomiting, diarrhea, cough, headache, peripheral edema
Drug-Drug Interactions
- Increases bioavailability of cyclosporine
- Decreases concentration of voriconazole
- Concentration of letermovir is increased by atorvastatin, sirolimus, and tacrolimus