Lead toxicity: Difference between revisions
From IDWiki
(Imported from text file) Â |
(→â€)  |
||
(2 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
− | == |
+ | ==Background== |
+ | ===Pathophysiology=== |
||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
+ | *Lead has multisystem effects, and is a powerful neurotoxin |
||
⚫ | |||
+ | ===Risk Factors=== |
||
⚫ | |||
+ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
+ | |||
⚫ | |||
⚫ | |||
⚫ | |||
+ | |||
− | ** Miscarriages and stillbirths Investigations |
||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
⚫ | |||
+ | **[[Miscarriage]] and [[stillbirth]] |
||
+ | |||
+ | ==Investigations== |
||
+ | |||
⚫ | |||
⚫ | |||
⚫ | |||
+ | |||
+ | == Diagnosis == |
||
+ | |||
+ | * Blood lead level strongly correlates with exposure level and health effects |
||
+ | ** Shows acute exposures (i.e. within months) |
||
+ | * Since lead deposits in the bones, can do X-ray defraction for cumulative lead exposure |
||
[[Category:Toxicology]] |
[[Category:Toxicology]] |
Latest revision as of 10:12, 23 October 2020
Background
Pathophysiology
- Lead has multisystem effects, and is a powerful neurotoxin
Risk Factors
- Occupational exposure to lead:
- Battery manufacturing
- Plumbing
- Mining
- Painting
- Paper hanging
- Auto repair
Clinical Manifestations
- Acute exposure
- Abdominal pain and constipation
- Headache, cognitive deficits, and peripheral neuropathy
- Myalgias and arthralgias
- Anemia
- Anorexia
- Chronic exposure
- Fatigue and insomnia
- Hypertension
- Neuropsychiatric symptoms
- Nephropathy
- Miscarriage and stillbirth
Investigations
- Labs:
- CBC showing microcytic anemia
- Peripheral blood film showing basophilic stippling
Diagnosis
- Blood lead level strongly correlates with exposure level and health effects
- Shows acute exposures (i.e. within months)
- Since lead deposits in the bones, can do X-ray defraction for cumulative lead exposure