Lead toxicity: Difference between revisions
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+ | ==Background== |
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+ | ===Pathophysiology=== |
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+ | *Lead has multisystem effects, and is a powerful neurotoxin |
===Risk Factors=== |
===Risk Factors=== |
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**[[Miscarriage]] and [[stillbirth]] |
**[[Miscarriage]] and [[stillbirth]] |
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+ | ==Investigations== |
*Labs: |
*Labs: |
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**CBC showing [[microcytic anemia]] |
**CBC showing [[microcytic anemia]] |
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**Peripheral blood film showing basophilic stippling |
**Peripheral blood film showing basophilic stippling |
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| + | == Diagnosis == |
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| + | * Blood lead level strongly correlates with exposure level and health effects |
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| + | ** Shows acute exposures (i.e. within months) |
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| + | * Since lead deposits in the bones, can do X-ray defraction for cumulative lead exposure |
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[[Category:Toxicology]] |
[[Category:Toxicology]] |
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Latest revision as of 10:12, 23 October 2020
Background
Pathophysiology
- Lead has multisystem effects, and is a powerful neurotoxin
Risk Factors
- Occupational exposure to lead:
- Battery manufacturing
- Plumbing
- Mining
- Painting
- Paper hanging
- Auto repair
Clinical Manifestations
- Acute exposure
- Abdominal pain and constipation
- Headache, cognitive deficits, and peripheral neuropathy
- Myalgias and arthralgias
- Anemia
- Anorexia
- Chronic exposure
- Fatigue and insomnia
- Hypertension
- Neuropsychiatric symptoms
- Nephropathy
- Miscarriage and stillbirth
Investigations
- Labs:
- CBC showing microcytic anemia
- Peripheral blood film showing basophilic stippling
Diagnosis
- Blood lead level strongly correlates with exposure level and health effects
- Shows acute exposures (i.e. within months)
- Since lead deposits in the bones, can do X-ray defraction for cumulative lead exposure
