John Cunningham virus: Difference between revisions
From IDWiki
No edit summary |
(added Clinical Presentation) |
||
| Line 1: | Line 1: | ||
* CNS infection with JC virus, usually in the context of HIV infection |
* CNS infection with JC virus, usually in the context of HIV infection |
||
| − | == |
+ | ==Background== |
| + | ===Epidemiology=== |
||
| − | |||
* HIV patients |
* HIV patients |
||
| + | ==Clinical Presentation== |
||
| ⚫ | |||
| + | * '''Classic PML''' |
||
| + | ** Subacute onset of focal central neurological lesions |
||
| + | ** Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI |
||
| + | * '''PML-IRIS''' |
||
| + | ** Focal central neurological lesions following immune recovery |
||
| + | ** Contrast enhancing lesions with or without mass effect on MRI |
||
| + | * '''JCV granule cell neuropathy''' |
||
| + | ** Chronic cerebellar dysfunction |
||
| + | ** Cerebellar atrophy on MRI |
||
| + | * '''JCV encephalitis''' |
||
| + | ** Subacute onset of encephalopathy |
||
| + | ** Cortical lesions on MRI |
||
| + | * '''JCV meningitis''' |
||
| + | ** Chronic headaches |
||
| + | ** Ventriculomegaly on MRI |
||
| ⚫ | |||
* MRI head: white matter changes |
* MRI head: white matter changes |
||
| − | == |
+ | ==Diagnosis== |
| − | |||
* JC virus PCR |
* JC virus PCR |
||
| − | == |
+ | ==Treatment== |
| − | |||
* Antiretroviral therapy for HIV |
* Antiretroviral therapy for HIV |
||
Revision as of 14:50, 23 May 2020
- CNS infection with JC virus, usually in the context of HIV infection
Background
Epidemiology
- HIV patients
Clinical Presentation
- Classic PML
- Subacute onset of focal central neurological lesions
- Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI
- PML-IRIS
- Focal central neurological lesions following immune recovery
- Contrast enhancing lesions with or without mass effect on MRI
- JCV granule cell neuropathy
- Chronic cerebellar dysfunction
- Cerebellar atrophy on MRI
- JCV encephalitis
- Subacute onset of encephalopathy
- Cortical lesions on MRI
- JCV meningitis
- Chronic headaches
- Ventriculomegaly on MRI
Investigations
- MRI head: white matter changes
Diagnosis
- JC virus PCR
Treatment
- Antiretroviral therapy for HIV
