Jaundice
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Revision as of 11:32, 19 January 2023 by Aidan (talk | contribs) (Created page with "== Etiologies == === Unconjugated Hyperbilirubinemia === * Overproduction: hemolysis, Wilson disease, extravasation, shunt yperbilirubinemia * Reduced uptake: portosystemic shunt, drugs, Gilbert syndrome * Conjugation defect ** Acquired: neonatal, maternal milk, Lucy-Driscoll, hyperthyroidism, chronic persistent hepatitis, advanced cirrhosis ** Inherited: Crigler-Najjar syndrome, Gilbert syndrome === Conjugated or Combined Hyperbilirubinemia ==...")
Etiologies
Unconjugated Hyperbilirubinemia
- Overproduction: hemolysis, Wilson disease, extravasation, shunt yperbilirubinemia
- Reduced uptake: portosystemic shunt, drugs, Gilbert syndrome
- Conjugation defect
- Acquired: neonatal, maternal milk, Lucy-Driscoll, hyperthyroidism, chronic persistent hepatitis, advanced cirrhosis
- Inherited: Crigler-Najjar syndrome, Gilbert syndrome
Conjugated or Combined Hyperbilirubinemia
- Intrahepatic cholestasis: PBC, PSC, viral hepatitis, progressive familial intrahepatis cholestasis, intrahepatic cholestasis of pregnancy, total parenteral nutrition, post-operative
- Drugs and toxins: alcoholic hepatitis, corticosteroids, chlorpromazine, some herbal medications, arsenic
- Infiltrative diseases, including amyloidosis, lymphoma, sarcoidosis, tuberculosis
- Sickle cell crisis
- Extrahepatic cholestasis: HIV cholangiopathy, choledocholithiasis, tumours, PSC, pancreatitis, strictures
- Some parasites: Ascaris lumbricoides, liver flukes
- Hepatocellular injury
- Defects in canalicular extretion or sinusoidal re-uptake: Dubin-Johnson syndrome, Rotor syndrome
