Infectious mononucleosis: Difference between revisions
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| + | == Background == |
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| + | === Microbiology === |
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| + | * [[Cytomegalovirus]] (20%) |
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| + | == Clinical Manifestations == |
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| + | * Syndrome of sore throat, fever, and lymphadenopathy |
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| + | * EBV-associated mono is the most common; see [[Epstein-Barr virus]] for more details |
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| + | * CMV-associated mono is usually milder than EBV, with less prominent lymphadenopathy but almost always with hepatitis |
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| + | == Differential Diagnosis == |
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| + | * Acute [[HIV]] infection, which more commonly has mucocutaneous ulcerations and a rash |
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| + | * [[Toxoplasmosis]], which usually does not have pharyngitis or hepatitis |
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| + | * Acute [[HHV-6]] and [[HHV-7]] |
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| + | == Investigations == |
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| + | * Patients with negative [[Epstein-Barr virus#Serology|heterophile antibody]] testing for EBV should have an [[HIV]] test |
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| + | == Management == |
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| + | * Generally supportive care |
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| + | [[Category:Head and neck infections]] |
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Latest revision as of 09:01, 18 August 2020
Background
Microbiology
- Epstein-Barr virus (80%)
- Cytomegalovirus (20%)
Clinical Manifestations
- Syndrome of sore throat, fever, and lymphadenopathy
- EBV-associated mono is the most common; see Epstein-Barr virus for more details
- CMV-associated mono is usually milder than EBV, with less prominent lymphadenopathy but almost always with hepatitis
Differential Diagnosis
- Acute HIV infection, which more commonly has mucocutaneous ulcerations and a rash
- Toxoplasmosis, which usually does not have pharyngitis or hepatitis
- Acute HHV-6 and HHV-7
Investigations
- Patients with negative heterophile antibody testing for EBV should have an HIV test
Management
- Generally supportive care
