Infectious causes of dementia

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Infectious causes of dementia

  • Bacterial
    • Syphilis, usually as general paralysis with emotional incontinence, irritability, grandiosity, euphoria, poor insight, apathy, delusions, and cognitive impairment
    • Lyme meningoencephalomyelitis, with impaired executive function and reduced attention
    • Sequela of bacterial meningitis
    • Whipple disease
  • Viral
    • Viral encephalitis (usually reversible)
      • Herpesviruses, including HSV-1, HSV-2, EBV, HHV-6, HHV-7 (and CMV and VZV, in immunocompromised people)
      • Arboviruses
      • Enteroviruses
    • HIV-associated dementia: motor slowing, depressed mood, impaired recall but not recognition, poor visuospatial skills, and impaired executive function
      • Also, HIV-associated opportunistic infections including toxoplasmosis, cryptococcus, and CMV
    • Hepatitis C virus
    • Measles (subacute sclerosing panencephalitis, SSPE)
  • Fungal
    • Cryptococcus
  • Parasitic
    • Neurocysticercosis (rarely)
  • Prion
    • Creutzfeld-Jakob disease