Human granulocytotropic anaplasmosis: Difference between revisions
From IDWiki
(Split species away from disease) |
m (Redirected page to Anaplasma phagocytophilum) Tag: New redirect |
||
| Line 1: | Line 1: | ||
| − | + | #REDIRECT [[Anaplasma phagocytophilum]] |
|
| − | |||
| − | = Clinical Presentation = |
||
| − | |||
| − | * Incubation period of 1 to 2 weeks |
||
| − | * Usually an acute undifferentiated fever |
||
| − | * Can be mild or severe |
||
| − | * Fever, headache, malaise, and myalgias are common |
||
| − | * Can also cause nausea, vomiting, diarrhea, cough, arthralgias, nuchal rigidity, and confusion |
||
| − | * Less than 10% have rash, most of which is concurrent Lyme disease |
||
| − | * 36% of cases require hospitalization, and it is severe in 3 to 7% |
||
| − | * Severe complications include respiratory failure, septic shock, rhabdomyolysis, hemorrhage, and opportunistic infections |
||
| − | ** Rare meningoencephalitis |
||
| − | * Higher case-fatality rate in Shandong Province in China, for no clear reason (16% versus 2.6%) |
||
| − | * Thrombocytopenia, lerkopenia, and mild anemia are common |
||
| − | ** Return to normal range within 14 days, but with persistent left shift |
||
| − | * Abnormal liver enzymes are common in the first 7 days |
||
| − | |||
| − | = Diagnosis = |
||
| − | |||
| − | * 20-80% of patients will have circulating neutrophils with detectable '''morulae''' on blood film (in neutrophils/granulocytes) |
||
| − | * Serology used to diagnose, by measuring IgG levels ≥1:64 or a fourfold rise |
||
| − | ** IgM testing less sensitive and specific |
||
| − | * Culture not done routinely |
||
| − | * PCR possible |
||
| − | |||
| − | = Management = |
||
| − | |||
| − | * Doxycycline 100 mg po bid |
||
Latest revision as of 13:42, 13 August 2019
Redirect to:
