High dose ARA-C

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Definition

  • High-dose cytarabine at 1,000-3,000 mg/m2 IV over 1-3 hours every 12 hours for 6 to 12 doses

Indications

  • Consolidation of AML and ALL

Side Effects

  • Cerebellar toxicity (ataxia)
  • Granulocytopenia, thrombocytopenia, leukopenia
  • GI disturbances, stomatitis, conjunctivitis, pneumonitis, fever, and dermatitis, palmar-plantar erythrodysesthesia
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