Haemophilus ducreyi: Difference between revisions
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Haemophilus ducreyi
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+ | ==Background== |
| − | * |
+ | *Causes '''chancroid''' |
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+ | ===Microbiology=== |
| − | * |
+ | *Fastidious Gram-negative bacillus |
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+ | ===Epidemiology=== |
| − | * |
+ | *Present worldwide |
| − | * |
+ | *Endemic when sex workers, for example, are pressured to have sex with multiple partners despite active genital lesions |
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+ | ==Clinical Manifestations== |
| − | * |
+ | *Presents initially with a papule at the site of inoculation, progressing to pustules, which rupture into painful, purulent, and shallow ulcers |
| − | ** |
+ | **Ulcer base often bleeds |
| − | ** |
+ | **In men, lesions are more common on the prepuce, coronal sulcus, or penile shaft |
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+ | **In women, lesions occur more commonly on external genitalia, but can also occur within the vagina or on the cervix |
| − | * |
+ | *Often multiple ulcers |
| − | * |
+ | *May have associated painful [[lymphadenitis]], which can drain |
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+ | ==Diagnosis== |
| + | *Not culturable |
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| − | * Culture for ''Haemophilus ducreyi'' from swab of lesion, or PCR if available |
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| + | *PCR if available |
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| + | *Most commonly diagnosed with tissue biopsy using Giemsa or Wright stains |
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| − | == |
+ | ==Management== |
| − | * |
+ | *First-line: [[Is treated by::ciprofloxacin]] 500 mg PO once |
| − | * |
+ | *Alternatives: [[Is treated by::erythromycin]] 500 mg PO tid for 7 days, [[Is treated by::azithromycin]] 1 g PO once, or [[Is treated by::ceftriaxone]] 250 mg IM once |
| − | * |
+ | *Rule out other STIs |
{{DISPLAYTITLE:''Haemophilus ducreyi''}} |
{{DISPLAYTITLE:''Haemophilus ducreyi''}} |
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Latest revision as of 12:16, 3 December 2020
Background
- Causes chancroid
Microbiology
- Fastidious Gram-negative bacillus
Epidemiology
- Present worldwide
- Endemic when sex workers, for example, are pressured to have sex with multiple partners despite active genital lesions
Clinical Manifestations
- Presents initially with a papule at the site of inoculation, progressing to pustules, which rupture into painful, purulent, and shallow ulcers
- Ulcer base often bleeds
- In men, lesions are more common on the prepuce, coronal sulcus, or penile shaft
- In women, lesions occur more commonly on external genitalia, but can also occur within the vagina or on the cervix
- Often multiple ulcers
- May have associated painful lymphadenitis, which can drain
Diagnosis
- Not culturable
- PCR if available
- Most commonly diagnosed with tissue biopsy using Giemsa or Wright stains
- Rule out other causes as appropriate with NAAT or PCR
Management
- First-line: ciprofloxacin 500 mg PO once
- Alternatives: erythromycin 500 mg PO tid for 7 days, azithromycin 1 g PO once, or ceftriaxone 250 mg IM once
- Rule out other STIs
