Ganciclovir: Difference between revisions
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* Guanosine nucleoside analogue similar to acyclovir |
* Guanosine nucleoside analogue similar to acyclovir |
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* Inhibits all [[human herpesviruses]] by inhibiting DNA polymerase |
* Inhibits all [[human herpesviruses]] by inhibiting DNA polymerase |
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| + | * Resistance in [[CMV]] |
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| − | * |
+ | ** Most often conferred by mutations of UL97 kinase, which is required in order to phosphorylate ganciclovir into its active form |
| + | ** Can also develop through mutations in the target UL54 DNA polymerase |
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* Oral bioavailability 6-8% |
* Oral bioavailability 6-8% |
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Revision as of 21:52, 23 October 2019
- Guanosine nucleoside analogue similar to acyclovir
- Inhibits all human herpesviruses by inhibiting DNA polymerase
- Resistance in CMV
- Most often conferred by mutations of UL97 kinase, which is required in order to phosphorylate ganciclovir into its active form
- Can also develop through mutations in the target UL54 DNA polymerase
- Oral bioavailability 6-8%
